Feeding intolerance, inflammation, and neurobehaviors in preterm infants.
Feeding intolerance, inflammation, and neurobehaviors in preterm infants.
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DOI：
10.1016/j.jnn.2016.09.009
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发表时间：
2017-06-01
期刊：
影响因子：
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通讯作者：
Pickler, Rita H
中科院分区：
文献类型：
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作者：
Moore, Tiffany A;Pickler, Rita H
目得：确定喂养不耐受（FI），炎症和神经发育的早期措施之间的关系可能为NICU临床医生和工作人员提供临床相关评估的基础。二次分析的目的是检查FI的关系，炎症标志物和/或神经行为在第一周的生命。METHODS：这是一个回顾性的，匹配的病例对照设计，数据来自114个婴儿出生在≤32周gestation.RESULTS：八个婴儿发展FI之前，充分的肠道喂养。这些婴儿更有可能有失调水平的细胞因子，特别是IL 6，和较低的神经发育评分相比，婴儿没有FI。结论：结果表明，生理失调和不成熟的神经系统可能有助于早产儿FI的现象。需要进一步研究以确定脑-肠-免疫轴在该人群中FI和其他GI并发症中的作用。
PURPOSE: Identifying relationships between feeding intolerance (FI), inflammation, and early measures of neurodevelopment may provide the basis for clinically relevant assessments for NICU clinicians and staff. The purpose of this secondary analysis was to examine the relationship of FI to inflammatory markers and/or neurobehaviors in the first week of life.METHODS: This was a retrospective, matched case-control design with data drawn from 114 infants born at ≤32 weeks gestation.RESULTS: Eight infants developed FI prior to full enteral feedings. These infants were more likely to have dysregulated levels of cytokines, specifically IL6, and lower neurodevelopmental scores compared to infants without FI.CONCLUSIONS: Results suggest physiologic dysregulation and an immature nervous system may contribute to the phenomenon of FI in preterm infants. Further research to identify the role of the brain-gut-immune axis on FI and other GI complications in this population is warranted.