Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging
Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging
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DOI：
10.1038/s41598-018-35888-1
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发表时间：
2018-11-26
影响因子：
4.6
通讯作者：
Noel, Peter B.
中科院分区：
文献类型：
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作者：
Kopp, Felix K.;Daerr, Heiner;Noel, Peter B.
本研究的目的是研究临床前光谱光子计数CT （SPCCT）原型与传统CT在肺部成像方面的比较。使用临床前SPCCT和常规CT在标准和高分辨率（HR-CT）模式下扫描定制的肺影，包括不同大小和形状的结节。用线性回归评价体积估计。用Dice相似系数评价形状相似度。通过MTF对各成像系统的空间分辨率进行了研究。主观回顾了SPCCT系统的兔肺图像。在评估体积估计时，线性回归显示SPCCT与CT和HR-CT相比效果最好，SPCCT、CT和HR-CT的均方根误差分别为21.3 mm(3)、28.5 mm(3)和26.4 mm(3)。SPCCT的Dice相似系数在所有结节形状和大小上均优于SPCCT（平均SPCCT: 0.90; CT: 0.85; hrct: 0.85）。10%的MTF从HR-CT的10.1 LP/cm提高到SPCCT的21.7 LP/cm。在动物实验中，SPCCT对小肺结构的视觉检查是优越的。总之，由于与传统CT相比，SPCCT原型具有更高的分辨率，因此具有改善肺部结构评估的潜力。
The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolution (HR-CT) mode. Volume estimation was evaluated by linear regression. Shape similarity was evaluated with the Dice similarity coefficient. Spatial resolution was investigated via MTF for each imaging system. In-vivo rabbit lung images from the SPCCT system were subjectively reviewed. Evaluating the volume estimation, linear regression showed best results for the SPCCT compared to CT and HR-CT with a root mean squared error of 21.3 mm(3), 28.5 mm(3) and 26.4 mm(3) for SPCCT, CT and HR-CT, respectively. The Dice similarity coefficient was superior for SPCCT throughout nodule shapes and all nodule sizes (mean, SPCCT: 0.90; CT: 0.85; HR-CT: 0.85). 10% MTF improved from 10.1 LP/cm for HR-CT to 21.7 LP/cm for SPCCT. Visual investigation of small pulmonary structures was superior for SPCCT in the animal study. In conclusion, the SPCCT prototype has the potential to improve the assessment of lung structures due to higher resolution compared to conventional CT.