Incremental direct and indirect costs of untreated vasomotor symptoms
Incremental direct and indirect costs of untreated vasomotor symptoms
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DOI：
10.1097/gme.0000000000000320
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发表时间：
2015-03-01
影响因子：
2.7
通讯作者：
Aupperle, Peter M.
中科院分区：
文献类型：
--
作者：
Sarrel, Philip;Portman, David;Aupperle, Peter M.
目的：大多数患有中度至重度血管痉挛症状（VMS）的女性未经治疗。这项回顾性配对队列研究旨在评估与未经治疗的VMS.Methods相关的医疗资源利用，工作损失和成本负担：使用健康保险索赔（1999-2011）匹配（1：1）未经治疗的VMS妇女与对照妇女使用倾向评分。医疗保健资源利用率，工作效率损失结果：在12个月的随访中，未接受治疗的VMS患者中，（n = 252，273;平均年龄，56岁）的医疗资源利用率显著高于对照队列中的女性：全因门诊访视增加82%（95% CI，81-83; P < 0.001），VMS相关门诊访视增加121%（95% CI，118-124; P < 0.001）。VMS女性患者每年每例患者的平均直接成本显著更高（直接成本差异，1，346美元; 95%CI，1，249 - 1，449; P < 0.001）。VMS女性有57%（95% CI，51-63; P < 0.001）间接工作生产力损失天数多于对照组，相当于与未经治疗的VMS相关的每例患者每年增加的间接成本为770美元（95% CI，726-816; P < 0.001）。这项研究表明，未经治疗的VMS与门诊就诊频率显着增加以及直接和间接成本增加有关。
Objective: Most women with moderate to severe vasomotor symptoms (VMS) are untreated. This retrospective matched-cohort study aims to evaluate the healthcare resource utilization, work loss, and cost burden associated with untreated VMS.Methods: Health insurance claims (1999-2011) were used to match (1: 1) women with untreated VMS with control women using propensity score. Healthcare resource utilization, work productivity loss (disability + medically related absenteeism), and associated costs were compared between cohorts.Results: During the 12-month follow-up, women with untreated VMS (n = 252,273; mean age, 56 y) had significantly higher healthcare resource utilization than women in the control cohort: 82% higher for all-cause outpatient visits (95% CI, 81-83; P < 0.001) and 121% higher (95% CI, 118-124; P < 0.001) for VMS-related outpatient visits. Mean direct costs per patient per year were significantly higher for VMS women (direct cost difference, US$1,346; 95% CI, 1,249-1,449; P < 0.001). VMS women had 57% (95% CI, 51-63; P < 0.001) more indirect work productivity loss days than controls, corresponding to an incremental indirect cost per patient per year associated with untreated VMS of US$770 (95% CI, 726-816; P < 0.001).Conclusions: This study shows that untreated VMS are associated with significantly higher frequency of outpatient visits and incremental direct and indirect costs.