Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog.
Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog.
复制标题
狗消化间期血浆生长抑素样免疫反应性。
DOI：
10.1172/jci110236
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Unger,RH
中科院分区：
文献类型：
--
作者：
Aizawa,I;Itoh,Z;Harris,V;Unger,RH
为了研究生长抑素与胃消化间期收缩（GIC）之间可能的生理关系，同时测定了4只清醒狗的胃运动活动和血浆生长抑素样免疫反应性（SLI）浓度，每只狗在两个不同的场合进行了研究。血浆SLI水平在GIC期间最高，在GIC停止后60和80分钟最低;血浆SLI的平均差异为41 +/- 6 pg/ml。当合成胃动素（一种已知的GIC刺激物）在血浆SLI水平较低的时期内以生理速率输注时，SLI升高至与收缩期观察到的值大致相同的值，并且观察到类似于自发发生的GIC。当合成的生长抑素（一种已知的内源性胃动素释放抑制剂）以使血浆SLI升高至约收缩期（0.1微克/千克/小时）观察到的水平的速率输注时，随后的GIC的出现显著延迟。这些结果与生长抑素在犬GIC调节中的生理作用一致，并表明胃动素和生长抑素之间存在相互关系。
To study possible physiologic relationships between somatostatin and the gastric interdigestive contractions (GIC), gastric motor activity, and plasma somatostatin-like immunoreactivity (SLI) concentration were determined simultaneously in four conscious dogs, each of which was studied on two separate occasions. Plasma SLI level was highest during the GIC period and lowest 60 and 80 min after the cessation of the GIC; the mean difference in plasma SLI was 41 +/- 6 pg/ml. When synthetic motilin, a known stimulus of GIC, was infused at a physiologic rate during the period in which plasma SLI levels were low, SLI rose to approximately the same values observed during the contraction period and GIC similar to those that occur spontaneously were observed. When synthetic somatostatin, a known inhibitor of endogenous motilin release, was infused at a rate that raised the plasma SLI to approximately the levels observed during the contraction period (0.1 microgram/kg per h), the appearance of the subsequent GIC was significantly delayed. These results are consistent with a physiological role for somatostatin in the regulation of GIC in dogs and suggest an interrelationship between motilin and somatostatin.