Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation
Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation
复制标题
DOI：
10.1039/c5cc09534d
复制
发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Zheng, Minhua
中科院分区：
文献类型：
--
作者：
Song, Haiqin;Kang, Xiang;Zheng, Minhua
将空间受阻的吡啶配体引入光敏铂(IV)药物中进行药物传递，其有效性比黄金标准顺铂提高了100倍。
The introduction of a sterically hindered pyridine ligand to a photosensitive platinum(IV) drug for drug delivery resulted in a >100 fold increase in effectiveness compared to the gold standard, cisplatin.