Compendium of fractionation choices for gynecologic HDR brachytherapy-An American Brachytherapy Society Task Group Report
Compendium of fractionation choices for gynecologic HDR brachytherapy-An American Brachytherapy Society Task Group Report
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DOI：
10.1016/j.brachy.2019.02.008
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发表时间：
2019-07-01
期刊：
影响因子：
1.9
通讯作者：
Yashar, Catherine
中科院分区：
文献类型：
--
作者：
Albuquerque, Kevin;Hrycushko, Brian A.;Yashar, Catherine
目得：本研究的目的是报告一系列公认的高剂量率（HDR）近距离放射治疗妇科癌症的分割方案，用于确定性、新辅助或辅助治疗。具有妇科近距离放射治疗专业知识的美国近距离放射治疗学会（ABS）工作组成员回顾了文献和现有的ABS指南，HDR近距离放射治疗的分次时间表来创建该概要。其他资源包括由医学协会出版的现行指南、临床试验、已出版的医学文献和ABS工作组成员的临床经验。对这些分次方案的HDR近距离放射治疗实践的ABS共识声明进行了审查，并形成了本报告的主要来源。具体的建议，治疗和建议，进一步调查时，有agreement.Results：各种剂量分割方案的HDR近距离放射治疗单独或整合近距离放射治疗与外部束辐射存在。根据患者的实践情况和可用资源，选择给定的分次时间表可能是适当的。虽然对于任何疾病部位或临床情况都没有单一的最佳剂量分次方案，但已知每种方案的分次剂量越高，分次剂量越少，毒性越大。相应的2-灰色（戈伊）每部分放射生物等效剂量已提供（归一化治疗剂量），以比较各种方案，其中指出，并可用于估计isofectible schedures.Conclusions：这一纲要的HDR近距离放射治疗分次时间表提供了各种选择的妇科近距离治疗师和一个现成的参考临床使用在妇科癌症治疗的管理。(C)2019年美国近距离放射治疗协会。爱思唯尔公司出版All rights reserved.
PURPOSE: The purpose of this study was to report a list of accepted fractionation schemes for high-dose-rate (HDR) brachytherapy for gynecological cancers in a definitive, neoadjuvant, or adjuvant setting.METHODS AND MATERIALS: Members of the American Brachytherapy Society (ABS) Task Force with expertise in gynecological brachytherapy reviewed the literature and existing ABS guidelines regarding various dose-fractionation schedules for HDR brachytherapy to create this compendium. Other resources include current guidelines published by medical societies, clinical trials, the published medical literature, and the clinical experience of the ABS Task Force members. The ABS consensus statements for HDR brachytherapy practice were reviewed for these fractionation schemes and form the major source for this report. Specific recommendations for therapy and recommendations for further investigations were made when there was agreement.RESULTS: A variety of dose-fractionation schedules for HDR brachytherapy alone or integrating brachytherapy with external-beam radiation exist. The choice of a given fractionation schedule may be appropriate depending on the practice situation for the patient and the resources available. While there is no single optimal dose-fractionation scheme for any disease site or clinical situation, higher doses per fraction with fewer fractions per regimen have been known to increase toxicity. The corresponding 2-Gray (Gy) per fraction radiobiologic equivalent doses have been provided (normalized therapy dose) to compare the various regimens where indicated and can be used to estimate isoeffective schedules.CONCLUSIONS: This compendium of HDR brachytherapy fractionation schedules provides various options to the gynecologic brachytherapist and a ready reference for clinical use in the management of gynecological cancer treatments. (C) 2019 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.