Significance of endoscopic deep small bowel evaluation using balloon-assisted enteroscopy for Crohn's disease in clinical remission
Significance of endoscopic deep small bowel evaluation using balloon-assisted enteroscopy for Crohn's disease in clinical remission
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球囊辅助小肠镜评估内镜深部小肠对克罗恩病临床缓解的意义
DOI：
10.1007/s12328-020-01261-x
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kanai T.
中科院分区：
文献类型：
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作者：
Takabayashi K;Hosoe N;Kato M;Hayashi Y;Nanki K;Fukuhara K;Mikami Y;Mizuno S;Sujino T;Mutaguchi M;Naganuma M;Yahagi N;Ogata H;Kanai T.
免疫检查点抑制剂（ICPI）已被报道在各种癌症中有效。它们过度激活免疫系统，导致频繁的免疫相关不良事件（irAE）。由ICPI引起的结肠炎是最常见的结肠炎之一，被称为免疫介导的结肠炎（IMC）。虽然IMC和炎症性肠病（IBD）在许多方面是相似的，但在既存IBD（如溃疡性结肠炎（UC）和克罗恩病（CD））患者中IMC的报道很少。既往存在的IBD是否与结肠炎的发展有关尚不清楚。在此，我们报告一位从IMC发展成严重溃疡性结肠炎的病例。这是一个重要的情况下，遵循时间进程的结肠炎发展。我们的结论表明，频繁的结肠镜检查对于患有慢性炎症性疾病（如UC）的患者的IMC管理非常重要。
Immune checkpoint inhibitors (ICPI) have been reported to be effective in various carcinomas. They excessively activate the immune system, resulting in frequent immune-related adverse events (irAEs). Colitis induced by ICPI is one of the most common and is known as immune-mediated colitis (IMC). Although IMC and inflammatory bowel disease (IBD) are similar in many respects, there are very few reports of IMC in patients with preexisting IBD such as ulcerative colitis (UC) and Crohn's disease (CD). Whether preexisting IBD is concerned with the development of the colitis is not well known. Here, we reported the case who developed severe ulcerative colitis which started from IMC. It is an important case to follow the time course of the colitis developed. Our conclusion indicated that frequent colonoscopy was important for the management of IMC in a patient who has suffered chronic inflammatory disease, such as UC.