Modulation of TIM-3 expression on NK and T cell subsets in HIV immunological non-responders
Modulation of TIM-3 expression on NK and T cell subsets in HIV immunological non-responders
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DOI：
10.1016/j.clim.2014.10.009
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发表时间：
2015-01-01
影响因子：
8.6
通讯作者：
Landay, Alan L.
中科院分区：
文献类型：
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作者：
de Kivit, Sander;Lempsink, Ludwijn J. R.;Landay, Alan L.
用于治疗 HIV 感染的高效抗逆转录病毒疗法 (HAART) 可维持病毒抑制并增加 HIV 患者的 CD4(+) T 细胞。然而，在 10-25% 的受试者（称为免疫无反应者 (INR)）中，HAART 不会增加 CD4 计数。我们研究了 galectin-9 和 TIM-3 在 INR 中的潜在作用，因为 galectin-9 和 TIM-3 已被描述为调节 NK 和 T 细胞功能。从健康对照、HIV 免疫应答者（IR，> 350 CD4(+) 细胞/mm(3)）和 HIV INR（
Highly active antiretroviral therapy (HAART) for the treatment of HIV infection sustains viral suppression and increases CD4(+) T cells in HIV patients. However, in 10-25% of subjects, known as immunological non-responders (INRs), HAART does not increase CD4 count. We investigated a potential role for galectin-9 and TIM-3 in INRs as galectin-9 and TIM-3 have been described to modulate NK and T cell function. PBMCs were isolated from healthy controls, HIV immunological responders (IRs, > 350 CD4(+) cells/mm(3)) and HIV INRs (