EFFECTS AND AFTEREFFECTS OF IBOGAINE ON MORPHINE SELF-ADMINISTRATION IN RATS
EFFECTS AND AFTEREFFECTS OF IBOGAINE ON MORPHINE SELF-ADMINISTRATION IN RATS
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DOI：
10.1016/0014-2999(91)90474-5
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发表时间：
1991-04-03
影响因子：
5
通讯作者：
CARLSON, JN
中科院分区：
文献类型：
--
作者：
GLICK, SD;ROSSMAN, K;CARLSON, JN
伊波甘是一种自然产生的生物碱，已被声称在治疗鸦片类药物和兴奋剂成瘾方面有效。作为对这一说法的临床前测试，本研究试图确定伊博甘是否会减少大鼠静脉注射吗啡的次数。伊波甘(2.5-80 mg/kg)剂量依赖性地减少了伊波甘治疗后一小时内的吗啡摄入量(急性效应)，并在较小程度上减少了一天后的吗啡摄入量(后效)；虽然急性效应可归因于异常运动行为(全身震颤)，但后效发生在伊布甘本应从体内完全消除并且没有明显的伊布甘暴露迹象的时候。在一些大鼠中，在单次注射伊博甘后的几天或几周内，吗啡的摄入量持续减少；另一些大鼠在每周注射两到三次后才开始显示出这种持续的变化，而少数大鼠显然对长期的后遗症具有抵抗力。后遗症不能归因于条件性厌恶。尽管伊博甘也抑制了被训练为喝水的大鼠的强烈反应，但一天或更长时间后，没有证据表明有任何后遗症；因此，伊博甘与吗啡强化之间的相互作用具有一定的特异性。还需要进一步的研究来确定伊波甘-吗啡相互作用的性质，以及确定伊波甘是否也影响其他药物的自我给药。
Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addiction to opiate and stimulant drugs. As a preclinical test of this claim, the present study sought to determine if ibogaine would reduce the intravenous self-administration of morphine in rats. Ibogaine dose dependently (2.5-80 mg/kg) decreased morphine intake in the hour after ibogaine treatment (acute effect) and, to a lesser extent, a day later (aftereffect); while the acute effect could be attributed to abnormal motor behavior (whole body tremors), the aftereffect occurred at a time when ibogaine should have been entirely eliminated from the body and when there was no obvious indication of ibogaine exposure. In some rats, there was a persistent decrease in morphine intake for several days or weeks after a single injection of ibogaine; other rats began to show such persistent changes only after two or three weekly injections whereas a few rats were apparently resistant to prolonged aftereffects. Aftereffects could not be attributed to a conditioned aversion. Although ibogaine also depressed responding acutely in rats trained to bar-press for water, there was no evidence of any aftereffect a day or more later; the interaction between ibogaine and morphine reinforcement was therefore somewhat specific. Further studies are needed to characterize the nature of the ibogaine-morphine interaction as well as to determine if ibogaine also affects the self-administration of other drugs.