Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
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DOI：
10.1038/sj.jhh.1001575
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发表时间：
2003-07-01
影响因子：
2.7
通讯作者：
Grobbee, DE
中科院分区：
文献类型：
--
作者：
Geleijnse, JM;Kok, FJ;Grobbee, DE
本研究的目的是评估血压对钠和钾摄入量变化的反应，并检查年龄、性别、血压、体重和习惯性钠和钾摄入量的影响。通过系统综述的参考文献列表和MEDLINE检索（1995年1月至2001年3月），确定了减少钠或补充钾与血压的随机试验。共选择了40项钠试验和27项钾试验进行分析，这些试验在成人中进行，最短持续时间为2周。收集了干预期间电解质摄入量和血压变化的数据，以及试验人群的平均年龄、性别、体重、初始电解质摄入量和初始血压的数据。通过加权荟萃回归分析评估电解质摄入量变化对血压的影响，包括总体和试验人群特征分层。重复分析，调整潜在混杂因素。钠减少（中位数：-77 mmol/24 h）与收缩压变化-2.54 mmHg（95% CI：-3.16，-1.92）和舒张压变化-1.96 mmHg（-2.41，-1.51）相关。钾摄入量增加的相应值（中位数：44 mmol/24 h）分别为-2.42 mmHg（-3.75，-1.08）和-1.57 mmHg（-2.65，-0.50）。高血压患者的血压反应大于血压正常者，无论是对钠（收缩压：-5.24 vs -1.26 mmHg，P
The objective of the study was to assess the blood pressure response to changes in sodium and potassium intake and examine effect modification by age, gender, blood pressure, body weight and habitual sodium and potassium intake. Randomised trials of sodium reduction or potassium supplementation and blood pressure were identified through reference lists of systematic reviews and an additional MEDLINE search (January 1995-March 2001). A total of 40 sodium trials and 27 potassium trials in adults with a minimum duration of 2 weeks were selected for analysis. Data on changes in electrolyte intake and blood pressure during intervention were collected, as well as data on mean age, gender, body weight, initial electrolyte intake and initial blood pressure of the trial populations. Blood pressure effects of changes in electrolyte intake were assessed by weighted metaregression analysis, overall and in strata of trial population characteristics. Analyses were repeated with adjustment for potential confounders. Sodium reduction (median: -77 mmol/24 h) was associated with a change of -2.54mmHg (95% CI: -3.16, -1.92) in systolic blood pressure and -1.96 mmHg (-2.41, -1.51) in diastolic blood pressure. Corresponding values for increased potassium intake (median: 44 mmol/24 h) were -2.42 mmHg (-3.75, -1.08) and -1.57 mmHg (-2.65, -0.50). Blood pressure response was larger in hypertensives than normotensives, both for sodium (systolic: -5.24 vs -1.26 mmHg, P