40 MHz high-frequency ultrafast ultrasound imaging
40 MHz high-frequency ultrafast ultrasound imaging
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DOI：
10.1002/mp.12244
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发表时间：
2017-06-01
期刊：
影响因子：
3.8
通讯作者：
Lee, Po-Yang
中科院分区：
文献类型：
--
作者：
Huang, Chih-Chung;Chen, Pei-Yu;Lee, Po-Yang
目的：基于相干平面波复合的超快高帧率超声成像技术已被广泛应用于生物医学领域。大多数相干平面波复合系统通常在3-15 MHz下工作，并且该频率范围的图像分辨率不足以使微结构组织可视化。因此，本研究的目的是实现一种工作在40 MHz的高频超快超声成像。方法：利用MATLAB的Field II工具箱对平面波复合成像和常规多聚焦B型成像进行仿真研究。在实验中，平面波复合图像从256通道超声研究平台与40 MHz阵列换能器获得。所有图像均由点扩散函数和囊肿体模生成。从斑马鱼进行体内实验。由于高频超声具有较低的穿透力，啁啾激励施加到增加的成像depth.Results：模拟结果表明，横向分辨率高达66.93 μ m和高达56.41 dB的对比度时，实现了使用75个角度的平面波在复合成像。实验结果表明，当采用75个角度的平面波进行复合成像时，横向分辨率可达74.83 μ m，对比度可达44.62dB。实验复合成像的死区深度约为1.2mm，复合噪声深度约为2.0mm。利用平面波复合成像技术可以清晰地观察到斑马鱼心脏的结构。结论：利用小于23个角度的复合成像技术可以获得高于1000帧/秒的帧率。而当平面波入射角大于10 °时，复合成像的横向分辨率约为72 μ m。这项研究显示了超快高帧率超声成像的最高工作频率。(C)2017年美国医学物理学家协会
Purpose: Ultrafast high-frame-rate ultrasound imaging based on coherent-plane-wave compounding has been developed for many biomedical applications. Most coherent-plane-wave compounding systems typically operate at 3-15 MHz, and the image resolution for this frequency range is not sufficient for visualizing microstructure tissues. Therefore, the purpose of this study was to implement a high-frequency ultrafast ultrasound imaging operating at 40 MHz.Methods: The plane-wave compounding imaging and conventional multifocus B-mode imaging were performed using the Field II toolbox of MATLAB in simulation study. In experiments, plane-wave compounding images were obtained from a 256 channel ultrasound research platform with a 40 MHz array transducer. All images were produced by point-spread functions and cyst phantoms. The in vivo experiment was performed from zebrafish. Since high-frequency ultrasound exhibits a lower penetration, chirp excitation was applied to increase the imaging depth in simulation.Results: The simulation results showed that a lateral resolution of up to 66.93 mu m and a contrast of up to 56.41 dB were achieved when using 75-angles plane waves in compounding imaging. The experimental results showed that a lateral resolution of up to 74.83 mu m and a contrast of up to 44.62 dB were achieved when using 75-angles plane waves in compounding imaging. The dead zone and compounding noise are about 1.2 mm and 2.0 mm in depth for experimental compounding imaging, respectively. The structure of zebrafish heart was observed clearly using plane-wave compounding imaging.Conclusions: The use of fewer than 23 angles for compounding allowed a frame rate higher than 1000 frames per second. However, the compounding imaging exhibits a similar lateral resolution of about 72 mu m as the angle of plane wave is higher than 10 angles. This study shows the highest operational frequency for ultrafast high-frame-rate ultrasound imaging. (C) 2017 American Association of Physicists in Medicine