IMMUNOPHAGOCYTIC PROPERTIES OF RETINAL-PIGMENT EPITHELIUM-CELLS
IMMUNOPHAGOCYTIC PROPERTIES OF RETINAL-PIGMENT EPITHELIUM-CELLS
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DOI：
10.1126/science.7444450
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
GLAGOV, S
中科院分区：
文献类型：
--
作者：
ELNER, VM;SCHAFFNER, T;GLAGOV, S
视网膜色素细胞从正常的猴子眼睛中取出，并在载玻片室中孵育。所有活色素细胞均牢固地粘附于玻璃。它们通过选择性结合和吞噬抗体或补体包被的红细胞，证明了IgG Fc部分和补体第3组分的表面受体。这些具有受体的吞噬细胞被鉴定为视网膜色素细胞。视网膜色素细胞通常被认为来源于神经组织，显然是光感受器细胞碎片的清除剂，并具有表面受体和吞噬功能，这在眼部防御中可能是重要的。
Retinal pigment cells were dislodged from normal monkey eyes and incubated in glass-slide chambers. All viable pigment cells adhered strongly to glass. They demonstrated surface receptors for the Fc portion of IgG and for the 3rd component of complement by selectively binding and phagocytizing antibody or complement-coated erythrocytes. These phagocytic cells with receptors were identified as retinal pigment cells by characteristic ultrastructural features. Retinal pigment cells, which are generally believed to be derived from neural tissue, apparently are scavengers of photoreceptor cell debris and have surface receptors and phagocytic functions that may be important in ocular defense.