Influence of Time Delay on the Estimated Lung Shunt Fraction on 99mTc-Labeled MAA Scintigraphy for 90Y Microsphere Treatment Planning
Influence of Time Delay on the Estimated Lung Shunt Fraction on 99mTc-Labeled MAA Scintigraphy for 90Y Microsphere Treatment Planning
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DOI：
10.1097/rlu.0000000000000241
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发表时间：
2013-12-01
影响因子：
10.6
通讯作者：
Deroose, Christophe Michel
中科院分区：
文献类型：
--
作者：
De Gersem, Ruth;Maleux, Geert;Deroose, Christophe Michel
Y-90微球疗法用于以安全有效的方式治疗原发性或转移性肝肿瘤的选定患者。作为Y-90-微球治疗的准备，Tc-99 m-MAA模拟程序对于评估颗粒分流到肺或胃肠道是必不可少的。我们研究了注射Tc-99 m-MAA的间隔时间和扫描时间对肺分流分数（LSF）的影响。4例继发性肝癌患者在注射~（99）Tc-MAA后5小时内进行了重复全身造影，观察到LSF的显著变化。看来示踪剂降解导致稍后时间点的LSF被严重高估。过高估计LSF可能导致剂量减少或取消计划的Y-90微球治疗。结论是注射和扫描之间的间隔应保持尽可能短。
Y-90-microspheres therapy is used to treat selected patients with primary or metastatic liver tumors in a safe and effective way. As a preparation for Y-90-microspheres treatment, a Tc-99m-macroaggregated albumin (Tc-99m-MAA) simulation procedure is essential to evaluate particle shunting to the lung or gastrointestinal tract. We investigated the effect of interval between injection of Tc-99m-MAA and time of scanning on the lung shunt fraction (LSF). In 4 patients with secondary hepatic malignancies who underwent repeated whole-body scintigraphy up to 5 hours after injection of Tc-99m-MAA, a marked change in LSF was observed. It appears that tracer degradation leads to an important overestimation of LSF at later time points. An overestimation of LSF can lead to dose reduction or canceling of the planned Y-90-microspheres treatment. It is concluded that the interval between injection and scanning should be kept as short as possible.