Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study.
Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study.
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DOI：
10.3892/ol.2015.4031
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发表时间：
2016-02
期刊：
影响因子：
2.9
通讯作者：
Libra M
中科院分区：
文献类型：
--
作者：
Hafsi S;Candido S;Maestro R;Falzone L;Soua Z;Bonavida B;Spandidos DA;Libra M
越来越多的研究强调了microRNAs(miRNAs或miRs)在癌症发生和发展中的作用。特别是，癌症相关蛋白的异常表达，如癌基因和肿瘤抑制因子，已被证明与特定miRNAs的表达调控有关。在本研究中，我们旨在确定哪些下调的miRNAs可能参与调控癌基因转录因子阴阳1(YY1)的表达。YY1已被报道在几种恶性肿瘤中过度表达，我们先前的研究强调了YY1水平与非霍奇金淋巴瘤(NHL)侵袭性行为之间的显著相关性。通过Silico方法确定了总共57个有可能靶向YY1的miRNAs。对公开可用的NHL数据集的搜索，包括配对的mRNA和miRNA数据(GSE23026)，强调了YY1的表达水平与包括miR-363、miR-200a、miR-23b、miR-15a和miR-15b在内的一组有限的miRNAs的表达水平之间的显著相关性(Pearson相关性，r>；0.5)。有趣的是，hsa-miR-363和hsa-miR-200A都属于在Burkitt淋巴瘤组织中发现与正常组织相比下调的前20个miRNAs。虽然进一步的验证研究是有必要的，但这两个与BLY1上调相关的miRNAs的识别可能会进一步深入了解这种肿瘤的发病机制，并可能有助于为这种疾病的患者提供更个性化和有针对性的治疗方法。
A growing number of studies have highlighted the role of microRNAs (miRNAs or miRs) in the development and progression of cancer. In particular, the aberrant expression of cancer-related proteins, such as oncogenes and tumor suppressors has been shown to correlate with the modulation of the expression of specific miRNAs. In the present study, we aimed to determine which downregulated miRNAs may be involved in modulating the expression of the oncogenic transcription factor, Yin Yang 1 (YY1). YY1 has been reported to be overexpressed in several malignancies and our previous studies have highlighted the significant correlation between the levels of YY1 and aggressive behavior in non-Hodgkin's lymphoma (NHL). A total of 57 miRNAs that are potentially capable of targeting YY1 was identified through in silico approaches. The search of publicly available NHL datasets, including paired mRNA and miRNA data (GSE23026) highlighted a significant correlation (Pearson's correlation, r>0.5) between the expression levels of YY1 and the expression levels of a limited set of miRNAs, including miR-363, miR-200a, miR-23b, miR-15a and miR-15b. Intriguingly, both hsa-miR-363 and hsa-miR-200a belong to the top 20 miRNAs that were found to be downregulated in Burkitt's lymphoma (BL) tissue compared to normal tissue. Although further validation studies are warranted, the identification of these two miRNAs associated with the upregulation of YY1 in BL may provide further insight into the pathogenesis of this tumor and may contribute to more personalized and targeted treatment approaches for patients with this disease.