Hippocampal neural activity reflects the economy of choices during goal-directed navigation.
Hippocampal neural activity reflects the economy of choices during goal-directed navigation.
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DOI：
10.1002/hipo.22720
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发表时间：
2017-07
期刊：
影响因子：
3.5
通讯作者：
Mizumori SJY
中科院分区：
文献类型：
--
作者：
Tryon VL;Penner MR;Heide SW;King HO;Larkin J;Mizumori SJY
区分空间背景对于海马体在情景记忆中众所周知的作用可能是必不可少的。我们研究了被认为是背景歧视基础的海马体神经组织类型是否受到选择行为的习得经济考虑的影响。当大鼠执行一项基于迷宫的概率折扣任务时，海马位置细胞和θ波活动被记录下来，该任务涉及在一个小的特定奖励和一个大的概率奖励之间做出选择。观察到位置场的空间分布随概率、大鼠选择的结果以及大鼠是否自由选择的变化而变化。奖赏位置由位置细胞表示的程度与奖赏的预期概率成比例。θ波能量在目标位置附近的增加也与信号奖励的预期概率成正比。此外，theta功率随着任务执行过程中“动态”获得的特定计量经济信息而动态变化。这种海马位置细胞记忆加工的经济视角扩展了我们对适应性导航过程中海马提取情境记忆本质的看法。
Distinguishing spatial contexts is likely essential for the well-known role of the hippocampus in episodic memory. We studied whether types of hippocampal neural organization thought to underlie context discrimination is impacted by learned economic considerations of choice behavior. Hippocampal place cells and theta activity were recorded as rats performed a maze-based probability discounting task that involved choosing between a small certain reward or a large probabilistic reward. Different spatial distributions of place fields were observed in response to changes in probability, the outcome of the rats’ choice, and whether or not rats were free to make that choice. The degree to which the reward location was represented by place cells scaled with the expected probability of rewards. Theta power increased around the goal location also in proportion to the expected probability of signaled rewards. Further, theta power dynamically varied as specific econometric information was obtained ‘on the fly’ during task performance. Such an economic perspective of memory processing by hippocampal place cells expands our view of the nature of context memories retrieved by hippocampus during adaptive navigation.