Autophagy during ageing – from Dr Jekyll to Mr Hyde
Autophagy during ageing – from Dr Jekyll to Mr Hyde
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DOI：
10.1111/febs.14453
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发表时间：
2018-07
期刊：
影响因子：
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通讯作者：
Thomas Wilhelm;H. Richly
中科院分区：
文献类型：
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作者：
Thomas Wilhelm;H. Richly
自噬是一种普遍存在的分解代谢过程，其通过囊泡吞噬废弃的、受损的或有害的细胞质组分而导致细胞体积降解。虽然自噬在发育和青年时期调节细胞稳态，但越来越多的证据表明自噬随着年龄的增长变得越来越不正常。最近在秀丽隐杆线虫中的研究甚至表明，晚期功能失调的自噬表现出驱动衰老过程的有害影响。其他研究将自噬的增加与健康和长寿密切联系起来。这篇综述旨在将这些明显相反的观点纳入视野，并定义我们目前对自噬在衰老过程中的作用的理解。
Autophagy is a ubiquitous catabolic process, which causes cellular bulk degradation through vesicular engulfment of obsolete, damaged or harmful cytoplasmic components. While autophagy regulates cellular homeostasis during development and in youth, there is mounting evidence that autophagy becomes increasingly dysfunctional with age. Recent work in Caenorhabditis elegans even suggests that late‐life dysfunctional autophagy exhibits detrimental effects that drive the ageing process. Other studies link elevated autophagy closely to increased health and longevity. This review aims to put these apparently opposing views into perspective and define our current understanding of the role of autophagy during ageing.