Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice.
Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice.
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DOI：
10.1038/srep16247
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发表时间：
2015-11-09
影响因子：
4.6
通讯作者：
Snijders AM
中科院分区：
文献类型：
--
作者：
Mao JH;Langley SA;Huang Y;Hang M;Bouchard KE;Celniker SE;Brown JB;Jansson JK;Karpen GH;Snijders AM
有证据表明，运动缺陷、肥胖和许多神经系统疾病之间存在联系。然而，对遗传风险因素的了解甚少。在这里，我们使用了协作杂交（CC），一个新的近交系小鼠，捕捉90%的实验室小鼠之间的已知变异的大面板，以确定控制转棒性能及其与体重的关系在一个队列中的365只小鼠在16个CC品系的遗传位点。体重和转棒性能在CC品系之间变化很大，并且呈显著负相关。遗传连锁分析确定了14个与体重相关的位点。然而，45个位点影响转棒性能，其中7个也与体重相关，这表明在遗传水平上有很强的联系。最后，我们表明，在这项研究中发现的基因与人类GWA研究中发现的神经系统疾病和肥胖相关的基因有显著重叠。总之，我们的研究结果为体重、中枢神经系统和行为之间的联系的研究提供了一个遗传框架。
Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred mice that captures 90% of the known variation among laboratory mice, to identify the genetic loci controlling rotarod performance and its relationship with body weight in a cohort of 365 mice across 16 CC strains. Body weight and rotarod performance varied widely across CC strains and were significantly negatively correlated. Genetic linkage analysis identified 14 loci that were associated with body weight. However, 45 loci affected rotarod performance, seven of which were also associated with body weight, suggesting a strong link at the genetic level. Lastly, we show that genes identified in this study overlap significantly with those related to neurological disorders and obesity found in human GWA studies. In conclusion, our results provide a genetic framework for studies of the connection between body weight, the central nervous system and behavior.