EVENT-RELATED POTENTIAL ABNORMALITIES CORRELATE WITH STRUCTURAL BRAIN ALTERATIONS AND CLINICAL-FEATURES IN PATIENTS WITH CHRONIC-SCHIZOPHRENIA
EVENT-RELATED POTENTIAL ABNORMALITIES CORRELATE WITH STRUCTURAL BRAIN ALTERATIONS AND CLINICAL-FEATURES IN PATIENTS WITH CHRONIC-SCHIZOPHRENIA
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DOI：
10.1016/0920-9964(94)90020-5
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发表时间：
1994-02-01
影响因子：
4.5
通讯作者：
WYATT, RJ
中科院分区：
文献类型：
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作者：
EGAN, MF;DUNCAN, CC;WYATT, RJ
精神分裂症患者似乎在大脑结构和信息处理方面都有异常。最近的几份报告表明，这些措施之间存在相关性。我们使用磁共振成像（MRI）检查了16例精神分裂症患者的几个脑区域的体积，并使用脑事件相关电位（ERPs）评估了信息处理和临床症状。实验对象通过听觉和视觉辨别任务进行测试。从相对概率为0.1的刺激引发的erp中，识别并测量了N100、N200和P300成分。所有受试者还进行了MRI扫描，包括12个连续的冠状面切片，每个1厘米厚。通过这些扫描，确定了以下结构并量化了体积或面积：第三脑室，侧脑室（部分），杏仁核和海马（一片），部分脑体积（通过顶叶的一片），以及两个皮质区域的前额叶和颞叶灰质和白质总量。海马区与听觉和视觉区N200、右侧海马区与视觉区P300的振幅呈显著相关。听觉P300与左颞叶结构测量之间的相关性较低但显著。听觉P300振幅与精神分裂症阳性症状呈负相关。这些初步结果表明，精神分裂症患者的ERP异常与颞叶病理有关。
Patients with schizophrenia appear to have abnormalities in both brain structures and information processing. Several recent reports have suggested that correlations exist between such measures. We examined the volume of several brain regions using magnetic resonance imaging (MRI), and also assessed both information processing, using brain event-related potentials (ERPs), and clinical symptomatology in sixteen medicated patients with schizophrenia. Subjects were tested using auditory and visual discrimination tasks. From the ERPs elicited by stimuli presented with relative probabilities of 0.1, the N100, N200, and P300 components were identified and measured. All subjects also had MRI scans that included 12 contiguous coronal sections, each 1 cm thick. From these scans, the following structures were identified and the volume or area quantified: third ventricle, lateral ventricles (partial), amygdala and hippocampus (one slice), partial brain volume (in one slice through the parietal lobe), and total prefrontal and temporal lobe gray and white matter in both cortical regions. Significant correlations were found between hippocampal area and the amplitude of the auditory and visual N200, and between the right hippocampus and the visual P300. Lower but significant correlations were seen between auditory P300 and measures of left temporal lobe structures. Auditory P300 amplitude correlated inversely with positive symptoms of schizophrenia. These preliminary results suggest that the ERP abnormalities in patients with schizophrenia are associated with temporal lobe pathology.