Cholesterol metabolism in the liver and intestine of the chick: Effect of dietary cholesterol, taurocholic acid and cholestyramine
Cholesterol metabolism in the liver and intestine of the chick: Effect of dietary cholesterol, taurocholic acid and cholestyramine
复制标题
雏鸡肝脏和肠道中的胆固醇代谢：日粮胆固醇、牛磺胆酸和考来烯胺的影响
作者：
D. Sklan;P. Budowski
采用体外组织切片法和体内静脉注射[14C]醋酸酯法，研究了饲喂胆固醇、牛磺胆酸和胆胺对雏鸡肝脏和肠道[1-14C]醋酸酯生成胆固醇的影响。在相同的治疗中，静脉注射[3H]胆固醇后，测量肝脏体内胆固醇向胆汁酸的转化。体外和体内肝脏胆固醇生成均受膳食胆固醇和牛磺胆酸抑制，而胆胺促进。体内肠道胆固醇生成仅被牛磺胆酸抑制，而体外回肠胆固醇生成则被膳食胆固醇降低。膳食胆固醇和胆胺促进胆固醇向胆汁酸的转化，牛磺酸胆酸抑制胆固醇向胆汁酸的转化。鸡的肝脏胆固醇代谢似乎受到与其他物种相似的机制的调节。
The effect of feeding cholesterol, taurocholic acid, or cholestyramine to chicks on cholesterolgenesis from [1-14C] acetate in liver and intestine was determined in vitro using tissue slices, and in vivo by i.v. injection of [14C] acetate. The conversion of cholesterol to bile acids in liver in vivo was measured in the same treatments after i.v. injection of [3H] cholesterol. Hepatic cholesterogenesis in vitro and in vivo was depressed by dietary cholesterol and taurocholate and enhanced by cholestyramine. Intestinal cholesterogenesis in vivo was depressed only by taurocholate whereas ileal cholesterogenesis in vitro was reduced by dietary cholesterol. Conversion of cholesterol to bile acids was enhanced by dietary cholesterol and cholestyramine and depressed by taurocholate. Hepatic cholesterol metabolism in the chick appears to be regulated by mechanisms similar to those reported for other species.