Potential for breath test diagnosis of urease positive pathogens in lung infections
Potential for breath test diagnosis of urease positive pathogens in lung infections
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DOI：
10.1088/1752-7163/ab2225
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发表时间：
2019-07-01
影响因子：
3.8
通讯作者：
Timmins, Graham S.
中科院分区：
文献类型：
--
作者：
Bishai, William R.;Timmins, Graham S.
尿素酶在幽门螺杆菌和泌尿道病原体的毒力中的作用是公认的。然而，尿素酶由引起新发和机会性肺部感染的细菌和真菌肺部病原体、引起慢性支气管炎急性加重的生物体、分枝杆菌肺部疾病如结核病（TB）以及呼吸机相关肺炎和卫生保健相关肺炎广泛表达。尿素酶的检测提供了一种方法，这些肺部病原体的吸入C-13-呼吸试验的快速体内检测，这篇综述讨论了肺部病原体的范围，可能是适合快速诊断。
Roles for urease in virulence are accepted for Helicobacter pylori and urinary tract pathogens. However, urease is widely expressed by bacterial and fungal lung pathogens causing emerging and opportunistic lung infections, organisms causing acute exacerbations of chronic bronchitis, mycobacterial lung diseases such as tuberculosis (TB), and ventilator associated pneumonia and health care associated pneumonia. Detection of urease provides a method for rapid in vivo detection of these lung pathogens by inhaled C-13-breath test, and this review discusses the range of lung pathogens that might be amenable to rapid diagnosis.