Sustained isometric contraction of skeletal muscle results in release of immunoreactive neurokinins in the spinal cord of the anaesthetized cat
Sustained isometric contraction of skeletal muscle results in release of immunoreactive neurokinins in the spinal cord of the anaesthetized cat
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骨骼肌的持续等长收缩导致麻醉猫脊髓中释放免疫反应性神经激肽
DOI：
10.1016/0304-3940(91)90855-n
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发表时间：
1991
影响因子：
2.5
通讯作者：
C. Williams
中科院分区：
文献类型：
--
作者：
A. Duggan;P. J. Hope;C. W. Lang;C. Williams
用抗体微探针研究麻醉后同侧后肢肌肉持续等距收缩后脊髓猫背角中免疫反应性神经激肽的释放。微探针在其外表面固定了针对神经激肽A （NKA）的抗体，并在插入中枢神经系统时结合一定比例的释放分子。从脊髓中取出微探针后，在放射自显像中检测到结合分子作为125i - nka结合减少的区域。左后肢采用环氧绷带夹板固定，并通过腹侧根的间歇性破伤风刺激引起肌肉的等距收缩。检测到免疫反应性神经激肽的基础存在，并通过持续的等长肌肉收缩增加。麦角受体可能含有并释放神经激肽。
Antibody microprobes were used to study release of immunoreactive neurokinins in the dorsal horn of the anaesthetized spinal cat following sustained isometric contraction of ipsilateral hindlimb muscles. Microprobes had immobilized antibodies to neurokinin A (NKA) on their outer surfaces and bound a proportion of released molecules when inserted in the central nervous system. Bound molecules were detected in autoradiographs as zones of reduced binding of125I-NKA in which microprobes were incubated after withdrawal from the spinal cord. The left hindlimb was immobilized using an epoxy bandage splint and isometric contraction of muscles induced by intermittent tetanic stimulation of a ventral root. A basal presence of immunoreactive neurokinins was detected and this was increased by sustained isometric muscle contraction. It is probable that ergoreceptors contain and release neurokinins.
P 物质拮抗剂减弱对肌肉收缩的反射升压反应。
影响因子：
2.9
作者：
Kaufman,MP;Kozlowski,GP;Rybicki,KJ
通讯作者：
Rybicki,KJ