Association between alcoholism and the dopamine D4 receptor gene
Association between alcoholism and the dopamine D4 receptor gene
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DOI：
10.1136/jmg.33.2.113
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发表时间：
1996-02-01
影响因子：
4
通讯作者：
Hayashida, M
中科院分区：
文献类型：
--
作者：
Muramatsu, T;Higuchi, S;Hayashida, M
乙醛脱氢酶2基因（ALDH 2（2）等位基因）的点突变被认为是酗酒的遗传障碍;然而，655名日本酗酒者中有80人具有突变等位基因。基因型因素可能会通过超越威慑而增加易感性，这些基因型因素显示，与100名其他酗酒者和144名对照相比，患有ALDH 2（2）的酗酒者多巴胺D4受体48 bp重复多态性的5个重复等位基因的频率更高。具有5个重复等位基因的酗酒者也更经常滥用其他药物。这些数据表明多巴胺系统参与了酗酒和其他成瘾行为的发展。
A point mutation in the aldehyde dehydrogenase 2 gene (ALDH2(2) allele) is considered to be a genetic deterrent for alcoholism; however, 80 of 655 Japanese alcoholics had the mutant allele. Genotype factors that might increase susceptibility by overriding the deterrent showed a higher frequency of a five repeat allele of the dopamine D4 receptor 48 bp repeat polymorphism in alcoholics with ALDH2(2) than in 100 other alcoholics and 144 controls. Alcoholics with the five repeat allele also abused other drugs more often. These data suggest the involvement of the dopamine system in the development of alcoholism and other addictive behaviour.