Noncoding RNAs: key molecules in understanding and treating pain.
Noncoding RNAs: key molecules in understanding and treating pain.
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DOI：
10.1016/j.molmed.2014.05.006
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发表时间：
2014-08
影响因子：
13.6
通讯作者：
Kuner R
中科院分区：
文献类型：
--
作者：
Bali KK;Kuner R
目前缺乏对调节疼痛的多种 ncRNA 的全面了解。在 ncRNA 中，miRNA 在疼痛调节方面的研究相对较多。 lncRNA 在疼痛调节方面也具有巨大潜力。 ncRNA 为治疗慢性疼痛提供了潜在的治疗选择。尽管非编码 RNA (ncRNA) 最初被认为是转录副产物，但最近的技术进步使我们对它们在基因调控和疾病发病机制中的重要性的了解不断加深。与这些发展保持一致，疼痛研究在 ncRNA 与病理性疼痛之间联系的调查方面也经历了快速增长。尽管最初的重点是分析候选 miRNA 的表达和失调，但对其他 ncRNA 和 ncRNA 介导的疼痛调节功能机制的阐明才刚刚开始。在这里，我们回顾了迄今为止关于疼痛调节的主要 ncRNA 文献，并讨论了可用于测试其他类型 ncRNA 对疼痛影响的工具和机会。
A comprehensive understanding of diverse ncRNAs in modulating pain is lacking. Among ncRNAs, miRNAs have been relatively well studied in pain regulation. lncRNAs also hold large potential for pain regulation. ncRNAs offer potential therapeutic options for treating chronic pain. Although noncoding RNAs (ncRNAs) were initially considered to be transcriptional byproducts, recent technological advances have led to a steady increase in our understanding of their importance in gene regulation and disease pathogenesis. In keeping with these developments, pain research is also experiencing rapid growth in the investigation of links between ncRNAs and pathological pain. Although the initial focus was on analyzing expression and dysregulation of candidate miRNAs, elucidation of other ncRNAs and ncRNA-mediated functional mechanisms in pain modulation has just commenced. Here we review the major ncRNA literature available to date with respect to pain modulation and discuss tools and opportunities available for testing the impact of other types of ncRNA on pain.
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影响因子：
11.1
作者：
Bali, Kiran Kumar;Selvaraj, Deepitha;Satagopam, Venkata P.;Lu, Jianning;Schneider, Reinhard;Kuner, Rohini
通讯作者：
Kuner, Rohini
影响因子：
64.8
作者：
Gong, Chenguang;Maquat, Lynne E.
通讯作者：
Maquat, Lynne E.
影响因子：
3.3
作者：
Bali KK;Hackenberg M;Lubin A;Kuner R;Devor M
通讯作者：
Devor M
影响因子：
14
作者：
Ghosh, Rajib;Singh, Lalithya C.;Gunaratne, Preethi H.
通讯作者：
Gunaratne, Preethi H.
影响因子：
48
作者：
Ebert, Margaret S.;Neilson, Joel R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.