Expression of integrin α2β1 in axons and receptive endings of neurons in rat, hairy skin
Expression of integrin α2β1 in axons and receptive endings of neurons in rat, hairy skin
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DOI：
10.1016/s0304-3940(00)01482-8
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发表时间：
2000-10-20
影响因子：
2.5
通讯作者：
Hadjiargyrou, M
中科院分区：
文献类型：
--
作者：
Khalsa, PS;Zhang, C;Hadjiargyrou, M
整合素α 2 β 1被认为是内皮细胞和肌肉细胞中的机械化学转换器。然而，很少有数据表明整合素是否在外周机械感觉神经元的机械转导过程中发挥作用。使用免疫组织化学，我们证明，皮肤神经元表达细胞外基质（ECM）受体整合素α 2 β 1。具体来说，我们表明整合素α 2和β 1与外周蛋白共同定位在大鼠毛茸茸的皮肤中皮肤神经元的感受性末梢中。整合素免疫荧光是最小的沿着大直径神经元的轴突。这些结果与其他研究人员的发现一起提供了证据，表明整合素α 2 β 1可能是ECM中机械应力与机械敏感神经元的神经元反应调制之间的联系剂。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Integrin alpha 2 beta 1 has been considered as a mechano-chemical transducer in endothelial and muscle cells. However, little data is available to show whether integrins play a role in the process of mechanical transduction in peripheral mechanosensory neurons. Using immunohistochemistry, we demonstrate that cutaneous neurons express the extracellular matrix (ECM) receptor integrin alpha 2 beta 1. Specifically, we show that integrins alpha 2 and beta 1 are co-localized with peripherin in the receptive endings of cutaneous neurons in rat, hairy skin. Integrin immunofluorescence was minimal along the axons of large diameter neurons. These results, together with findings by other investigators, provide evidence suggesting that integrin alpha 2 beta 1 may be a linking agent between mechanical stress in the ECM and modulation of the neuronal response of mechanically sensitive neurons. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.