Pulsed laser deposition of thin film hydroxyapatite. Applications for flexible catheters.
Pulsed laser deposition of thin film hydroxyapatite. Applications for flexible catheters.
复制标题
脉冲激光沉积薄膜羟基磷灰石。
DOI：
10.1097/00002480-199407000-00126
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发表时间：
1994
期刊：
影响因子：
4.2
通讯作者：
R. Auyeung
中科院分区：
文献类型：
--
作者：
P. Zabetakis;C. M. Cotell;D. Chrisey;R. Auyeung
皮肤出口部位感染是留置经皮导管患者发病的主要原因。陶瓷材料，如羟基磷灰石（HA）和氧化铝，已被证明具有良好的生物相容性和低感染率的软组织。先前设计陶瓷材料用作经皮连接器的尝试已导致刚性盘或实心圆柱形管。为了利用HA的固有特性而不降低患者的舒适度或活动性，研究了将HA薄膜直接施加到柔性聚合物导管上的可行性。通过脉冲激光沉积（PLD）施加涂层。来自KrF准分子激光器的光束撞击在压制和烧结的HA靶上，产生沉积在导管管路上的烧蚀材料的羽流。通过旋转管，以约0.50微米的厚度将均匀的HA涂层施加到导管上。涂层不会损害导管管路的柔韧性。因此，在经皮导管的出口部位处的HA薄膜的PLD可以是将HA的生物活性和生物相容性与表征聚合物导管的移动性和患者舒适性结合的手段。
Skin exit site infections are a major source of morbidity in patients with indwelling percutaneous catheters. Ceramic materials, such as hydroxyapatite (HA) and alumina, have demonstrated excellent biocompatibility and low rates of infection in soft tissues. Previous attempts to design ceramic materials for use as percutaneous connectors have resulted in rigid discs or solid cylindrical tubes. In order to take advantage of the inherent properties of HA without reducing patient comfort or mobility, the feasibility of applying a thin film of HA directly onto a flexible polymeric catheter was studied. The coating was applied by pulsed laser deposition (PLD). The beam from a KrF excimer laser impinged upon a target of pressed and sintered HA, producing a plume of ablated material that was deposited onto the catheter tubing. By rotating the tubing, an even coating of HA was applied to the catheter at a thickness of approximately 0.50 microm. The coating did not compromise the flexibility of the catheter tubing. Hence, PLD of a thin film of HA at the exit site of percutaneous catheters may be a means of incorporating the bioactive and biocompatible properties of HA with the mobility and patient comfort that characterize polymeric catheters.