As soon as possible in IgE-cow's milk allergy immunotherapy
As soon as possible in IgE-cow's milk allergy immunotherapy
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DOI：
10.1007/s00431-020-03731-3
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发表时间：
2020-07-11
影响因子：
3.6
通讯作者：
Aliaga Mazas, Yolanda
中科院分区：
文献类型：
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作者：
Bone Calvo, Javier;Clavero Adell, Marcos;Aliaga Mazas, Yolanda
口服免疫疗法是牛奶蛋白过敏的常见治疗方法。萨拉戈萨儿童医院儿科过敏科对 335 名被诊断患有 IgE 介导的牛奶并接受早期治疗的 1 岁以下婴儿进行了回顾性分析。在治疗开始前和结束后进行临床评估、皮肤点刺试验和血清特异性IgE水平控制。治疗完成后，98%以上的患者对牛奶产生了耐受性，并且没有人出现严重不良反应。如今，剩下的不耐受患者（1.8%）可以每天服用一定最大剂量的牛奶或衍生物作为预防，并且仍然保持无症状。免疫治疗后，随着对牛奶脱敏的增加，皮肤点刺试验呈阳性，特异性 IgE 水平逐渐下降。结论：口服免疫疗法是治疗婴儿牛奶蛋白过敏的安全有效的治疗方法。从诊断的第一刻起，就应该向儿童的家人提供这种治疗。
Oral immunotherapy is a common treatment in cow's milk protein allergy. The Department of Pediatric Allergology at the Children's Hospital of Zaragoza performed a retrospective analysis of 335 infants under 1 year of age diagnosed with IgE-mediated cow's milk and early treated. Clinical evaluation, skin prick test, and serum-specific IgE level control were performed before starting and after finishing treatment. Upon completion of treatment, more than 98% of patients became tolerant to milk and no one presented serious adverse reactions. Nowadays, the remaining non-tolerant patients (1.8%) can take milk or derivatives daily-as prophylaxis-to a certain maximum dose and still remain asymptomatic. After immunotherapy, both positive skin prick tests and a progressive decrease in specific IgE levels were found, as desensitization to milk increased.Conclusion: Oral immunotherapy is a safe and effective treatment against allergy to cow's milk proteins in infants. Such treatment should be offered to the children's families from the first moment of diagnosis.