Contributed Session II: Binocular combination of the pupil response depends on photoreceptor pathway
Contributed Session II: Binocular combination of the pupil response depends on photoreceptor pathway
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贡献会议 II：瞳孔反应的双眼组合取决于光感受器通路
DOI：
10.1167/jov.23.15.77
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发表时间：
2023
影响因子：
1.8
通讯作者：
Segala F
中科院分区：
文献类型：
--
作者：
Segala F
瞳孔的光反应由三类视网膜感光器驱动。视锥细胞和视杆细胞参与瞳孔的初始收缩，而含有黑视蛋白的固有光敏视网膜神经节细胞（ipRGC）在较长的时间尺度上保持收缩。以前的工作的特点是光感受器信号的瞳孔控制的贡献，但相对较少的是知道这些信号的双目组合时，同时刺激视网膜在两只眼睛。我们测量了48名参与者的瞳孔大小的变化，使用双目眼跟踪仪，针对特定的感光器类与双目10原色光引擎和沉默的替代方法。我们使用0.4和0.5 Hz的光闪烁刺激视网膜的周边。参与者观看了一个无彩色闪烁光的光盘，或针对ipRGC或对手颜色通路LM或S-（L+ M）的对比度调制。使用修改后的虚拟现实耳机，我们提出了在一系列的调制幅度在三个不同的眼睛配置的刺激：单眼，双眼，和双视。我们在第一和第二谐波频率下获得了清晰的瞳孔响应。不同条件下的抑制水平不同，LM条件下测得的抑制最强。我们占在一个单一的建模框架，其中的权重interocular抑制确定的双目组合属性的结果。
The pupillary light response is driven by three classes of retinal photoreceptor. Cones and rods are involved in the initial constriction of the pupil, whereas melanopsin-containing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) maintain constriction over longer timescales. Previous work has characterized the contributions of photoreceptor signals to pupil control, but relatively little is known about binocular combination of these signals when simultaneously stimulating the retina in both eyes. We measured changes in pupil size in 48 participants using a binocular eye-tracker, targeting specific photoreceptor classes with a binocular 10-primary light engine and the silent substitution method. We stimulated the periphery of the retina using light flickering at 0.4 and 0.5 Hz. Participants viewed a disc of either achromatic flickering light, or contrast modulations that targeted the ipRGCs, or the opponent colour pathways LM or S-(L+ M). Using a modified virtual reality headset, we presented the stimuli at a range of modulation amplitudes in three different ocular configurations: monocular, binocular, and dichoptic. We obtained clear pupil responses at both the first and the second harmonic frequencies. Suppression levels differed across conditions with the strongest suppression measured for the LM condition. We account for the results in a single modelling framework where the weight of interocular suppression determines the binocular combination properties.