Neural Effect of Real Time fMRI Based Working Memory Neurofeedback Training on the Cortico-Subcortico-Cerebellar Circuit
Neural Effect of Real Time fMRI Based Working Memory Neurofeedback Training on the Cortico-Subcortico-Cerebellar Circuit
复制标题
基于实时功能磁共振成像的工作记忆神经反馈训练对皮质-皮质下-小脑回路的神经效应
DOI：
10.1166/jmihi.2016.1921
复制
发表时间：
2016-09
影响因子：
--
通讯作者：
Xiaojie Zhao
中科院分区：
文献类型：
--
作者：
Gaoyan Zhang;Li Yao;Xiaojie Zhao
真实的实时功能磁共振成像（rtfMRI）神经反馈已被建议作为改善个体认知功能的科学工具。利用这种方法，我们最近发现，工作记忆的性能可以提高通过自我调节的大脑活动在背外侧前额叶皮层（DLPFC）。然而，rtfMRI神经反馈训练的神经效应不是很清楚。越来越多的来自健康受试者和临床患者的证据表明，皮质-皮质下-小脑回路与工作记忆密切相关。在这项研究中，我们集中在rtfMRI训练对这个皮质-皮质下-小脑回路的影响。结果表明，在训练过程中，该回路的功能连通性得到了显著改善。具体来说，丘脑，电路中的一个整合区域，与其他区域的连接性改善最多。此外，连接强度的提高与工作记忆更新任务绩效的提高呈正相关。本研究的发现进一步加深了我们对神经反馈训练优化工作记忆功能的脑机制的理解。通过rtfMRI训练增加回路连接性，为将来修复工作记忆缺陷患者回路中受损的连接提供了一些启示。
Real time functional MRI (rtfMRI) neurofeedback has been suggested as a scientific tool for improving individual cognitive function. Using this method, we recently found that working memory performance could be improved by self-regulating the brain activity in the dorsal lateral prefrontal cortex (DLPFC). However, the neural effect of the rtfMRI neurofeedback training is not very clear. Increasing evidence from healthy subjects and clinical patients has indicated that the cortico-subcortico-cerebellar circuit is closely related to working memory. In this study, we concentrated on the effect of rtfMRI training on this cortico-subcortico-cerebellar circuit. The results showed that the functional connectivity in this circuit was significantly improved during the training. Specifically, the thalamus, an integration region in the circuit, showed the most improved connectivity with other regions. Moreover, the improvement in connection strengths exhibited a positive correlation with the promotion of working memory updating task performance. The findings in this study advance our understanding of brain mechanism for optimizing working memory function by neurofeedback training. The increases in circuit connectivity by rtfMRI training give some implications for repairing the impaired connection in this circuit in patients with working memory deficits in the future.