Efficacy of the delta neutrophil index in predicting 30-day mortality in COVID-19 patients requiring intensive care
Efficacy of the delta neutrophil index in predicting 30-day mortality in COVID-19 patients requiring intensive care
复制标题
DOI：
10.1111/ijcp.13970
复制
发表时间：
2021-01-06
影响因子：
2.6
通讯作者：
Erdem, Deniz
中科院分区：
文献类型：
--
作者：
Birben, Birkan;Birben, Ozlem Duvenci;Erdem, Deniz
冠状病毒19是一种快速进展的疾病，可导致死亡。我们的目的是评估δ中性粒细胞指数在预测重症监护患者冠状病毒19的死亡率的有效性。材料和方法聚合酶链反应试验阳性和/或计算机断层扫描结果符合疾病的患者被纳入研究。患者的人口统计学特征，聚合酶链反应试验结果，胸部计算机断层扫描结果，血液参数在介绍时，30天的死亡率，并在重症监护室的天数进行了assessed.Results的388例接受重症监护，220（56.7%）是男性和168（43.3%）是女性。平均年龄为70 ± 15岁。死亡率评价：存活264例（68%），死亡124例（32%）。死亡组的中性粒细胞δ指数、中性粒细胞淋巴细胞比率、乳酸、白细胞介素-6和C反应蛋白值在统计学上显著较高，淋巴细胞值显著较低（分别为P = 0.003、0.034、0.000、0.002、0.000和0.024）。在受试者工作特征曲线分析中，中性粒细胞δ指数、淋巴细胞、中性粒细胞淋巴细胞比率、乳酸、白细胞介素6和C反应蛋白水平预测死亡率的曲线下面积分别为0.718、0.416、0.628、0.585、0.701和0.684。结论中性粒细胞δ指数可作为冠状病毒19感染患者重症监护死亡率的有效预测指标。
Objectives Coronavirus-19 is a rapidly progressing disease that can result in mortality. We aimed to evaluate the efficacy of the delta neutrophil index in predicting mortality in intensive care patients diagnosed with Coronavirus-19.Materials and methods Patients with a positive polymerase chain reaction test and/or computed tomography findings compatible with the disease were included in the study. The demographic characteristics of the patients, polymerase chain reaction test results, chest computed tomography findings, blood parameters at the time of presentation, 30-day mortality, and the number of days in the intensive care unit were assessed.Results Of the 388 patients receiving intensive care, 220 (56.7%) were men and 168 (43.3%) were women. The mean age was 70 +/- 15 years. The evaluation of mortality, 264 (68%) of the patients survived and 124 (32%) died. The delta neutrophil index, neutrophil lymphocyte ratio, lactate, interleukin-6 and C-reactive protein values were statistically significantly higher and the lymphocyte value was significantly lower in the mortality group (P = .003, .034, .000, .002, .000 and .024, respectively). In the receiver operating characteristic curve analysis, the area under the curve values of the delta neutrophil index, lymphocyte, neutrophil lymphocyte ratio, lactate, interleukin-6 and C-reactive protein levels in predicting mortality were 0.718, 0.416, 0.628, 0.585, 0.701 and 0.684, respectively.Conclusion We consider that the delta neutrophil index can be used as an effective prognostic parameter to show intensive care mortality in patients with Coronavirus-19.