Temporal Stability of the Human Skin Microbiome.
Temporal Stability of the Human Skin Microbiome.
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DOI：
10.1016/j.cell.2016.04.008
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发表时间：
2016-05-05
期刊：
影响因子：
64.5
通讯作者：
Segre JA
中科院分区：
文献类型：
--
作者：
Oh J;Byrd AL;Park M;NISC Comparative Sequencing Program;Kong HH;Segre JA
生物地理学和个性塑造了人体皮肤微生物组的结构和功能组成。为了探索这些因素对皮肤微生物群落稳定性的贡献，我们从数月和数年收集的纵向样本中生成宏基因组序列数据。使用多王国，基于参考的方法分析这些样本，我们发现，尽管皮肤暴露于外部环境，但其细菌，真菌和病毒群落随着时间的推移基本上是稳定的。网站，个性，和同源性都是这种稳定性的决定因素;脚网站表现出最大的变异性，个人不同的稳定性，和短暂性是真核病毒的一个特殊特征，这表明很少的位点特异性的殖民。菌株和单核苷酸变异水平分析表明，个体保持，而不是重新获得来自环境的流行微生物。皮肤微生物群落的纵向稳定性产生了关于定植抗性的假设，并使探索疾病状态中观察到的变化的临床研究成为可能。
Biogeography and individuality shape the structural and functional composition of the human skin microbiome. To explore these factors’ contribution to skin microbial community stability, we generated metagenomic sequence data from longitudinal samples collected over months and years. Analyzing these samples using a multi-kingdom, reference-based approach, we found that despite the skin’s exposure to the external environment, its bacterial, fungal, and viral communities were largely stable over time. Site, individuality, and phylogeny were all determinants of this stability; foot sites exhibited the most variability, individuals differed in stability, and transience was a particular characteristic of eukaryotic viruses, which showed little site-specificity in colonization. Strain and single nucleotide variant level analysis showed that individuals maintain, rather than reacquire prevalent microbes from the environment. Longitudinal stability of skin microbial communities generates hypotheses about colonization resistance and empowers clinical studies exploring alterations observed in disease states.