Improved detection limits using a hand-held optical imager with coregistration capabilities.
Improved detection limits using a hand-held optical imager with coregistration capabilities.
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DOI：
10.1364/boe.1.000126
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发表时间：
2010-07-15
影响因子：
3.4
通讯作者：
Godavarty A
中科院分区：
文献类型：
--
作者：
Erickson SJ;Martinez SL;Gonzalez J;Caldera L;Godavarty A
光学成像作为一种非侵入性和非电离的乳腺癌诊断方法正在兴起。一个手持光学成像仪已经开发出与coregistration设施对不同的组织体积和曲率在近实时的灵活成像。在此，进行荧光增强光学成像实验，以证明在（液体）组织体模和体外的完美和不完美（100：1）吸收条件下更深入的目标检测。在多次扫描（荧光强度图像）的总和时，在比单独的单次扫描更大的深度处检测荧光靶。
Optical imaging is emerging as a non-invasive and non-ionizing method for breast cancer diagnosis. A hand-held optical imager has been developed with coregistration facilities towards flexible imaging of different tissue volumes and curvatures in near real-time. Herein, fluorescence-enhanced optical imaging experiments are performed to demonstrate deeper target detection under perfect and imperfect (100:1) uptake conditions in (liquid) tissue phantoms and in vitro. Upon summation of multiple scans (fluorescence intensity images), fluorescent targets are detected at greater depths than from single scan alone.