Unirhinal olfactory function in schizophrenia patients and first-degree relatives
Unirhinal olfactory function in schizophrenia patients and first-degree relatives
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DOI：
10.1176/appi.neuropsych.18.3.389
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发表时间：
2006-06-01
影响因子：
2.9
通讯作者：
Moberg, Paul J.
中科院分区：
文献类型：
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作者：
Roalf, David R.;Turetsky, Bruce I.;Moberg, Paul J.
以前的研究报告，在气味识别的精神分裂症患者和他们的家庭成员birhinal障碍。作者在精神分裂症患者、健康一级亲属和健康对照受试者中进行了单嗅气味识别和检测阈值敏感性试验。患者和家庭成员在两个鼻孔的气味识别性能表现出赤字。气味检测阈值仅在患者和健康对照受试者之间存在差异。在患者和健康的家庭成员的气味识别赤字相比较，气味识别措施可能作为一个敏感的内表型脆弱性标记，单嗅嗅觉措施是精确的，如果不是更好，比birhinal性能措施。
Previous studies report birhinal impairments in odor identification in patients with schizophrenia and their family members. The authors employed unirhinal odor identification and detection threshold sensitivity tests in schizophrenia patients, healthy first-degree family members, and healthy comparison subjects. Patients and family members showed deficits in odor identification performance in both nostrils. Odor detection thresholds differed only between patients and healthy comparison subjects. Comparable odor identification deficits in both patients and healthy family members suggest that odor identification measures may serve as a sensitive endophenotypic vulnerability marker and that unirhinal olfactory measures are as precise, if not more so, than birhinal performance measures.