Cell surface as a fractal: normal and cancerous cervical cells demonstrate different fractal behavior of surface adhesion maps at the nanoscale.
Cell surface as a fractal: normal and cancerous cervical cells demonstrate different fractal behavior of surface adhesion maps at the nanoscale.
复制标题
DOI：
10.1103/physrevlett.107.028101
复制
发表时间：
2011-07-08
影响因子：
8.6
通讯作者：
Sokolov I
中科院分区：
文献类型：
--
作者：
Dokukin ME;Guz NV;Gaikwad RM;Woodworth CD;Sokolov I
在这里，我们表明，人类宫颈上皮细胞的表面表现出显着不同的分形行为时，细胞癌变。分析使用HarmoniX模式下操作的原子力显微镜获得的单个宫颈细胞的粘附图，我们发现癌细胞表现出简单的分形行为，而正常细胞最多只能近似为多重分形。对从12个人身上收集的约300个细胞进行测试，发现癌细胞的分形维数明显高于正常细胞。
Here we show that the surface of human cervical epithelial cells demonstrates substantially different fractal behavior when the cell becomes cancerous. Analyzing the adhesion maps of individual cervical cells, which were obtained using the atomic force microscopy operating in the HarmoniX mode, we found that cancerous cells demonstrate simple fractal behavior, whereas normal cells can only be approximated at best as multifractal. Tested on ~300 cells collected from 12 humans, the fractal dimensionality of cancerous cells is found to be unambiguously higher than that for normal cells.