The role of electrospinning in the emerging field of nanomedicine
The role of electrospinning in the emerging field of nanomedicine
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DOI：
10.2174/138161206779026326
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Leong, K. W.
中科院分区：
文献类型：
--
作者：
Chew, S. Y.;Wen, Y.;Leong, K. W.
在体内，细胞与细胞相互作用的细胞外基质(ECM)或底物通常包括纳米级的形貌，这一事实突显了研究细胞-底物相互作用和进行亚微米级细胞培养的重要性。纳米医学研究的一个重要和令人兴奋的方向是了解和开发细胞对纳米结构的反应。电纺是一种简单而通用的技术，可以生产出由随机取向或排列的纳米纤维组成的大孔支架。它还可以将药物输送功能结合到纤维支架中。这种电纺纳米纤维支架同时具有地形和生物化学信号，可以为种子细胞提供最佳的微环境。本文综述了静电纺丝过程的分析和控制，并介绍了用于药物输送和组织工程等生物医学应用的静电纺丝纤维的类型。
The fact that in vivo the extracellular matrix (ECM) or substratum with which cells interact often includes topography at the nanoscale underscores the importance of investigating cell-substrate interactions and performing cell culture at the submicron scale. An important and exciting direction of research in nanomedicine would be to gain an understanding and exploit the cellular response to nanostructures. Electrospinning is a simple and versatile technique that can produce a macroporous scaffold comprising randomly oriented or aligned nanofibers. It can also accommodate the incorporation of drug delivery function into the fibrous scaffold. Endowed with both topographical and biochemical signals such electrospun nanofibrous scaffolds may provide an optimal microenvironment for the seeded cells. This review covers the analysis and control of the electrospinning process, and describes the types of electrospun fibers fabricated for biomedical applications such as drug delivery and tissue engineering.