How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations
How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations
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DOI：
10.1016/j.sbi.2012.01.007
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发表时间：
2012-04-01
影响因子：
6.8
通讯作者：
Grubmueller, Helmut
中科院分区：
文献类型：
--
作者：
Risselada, Herre Jelger;Grubmueller, Helmut
SNARE分子是促进突触囊泡与突触前质膜融合的蛋白质机制的核心成分，导致神经递质的释放。在分子水平上，SNARE复合物似乎在融合的所有阶段都发挥着非常多功能和参与的作用。除了仅仅通过迫使相对的膜紧密靠近来触发融合之外，现在看到SNARE复合物还克服了随后的融合障碍，并积极引导融合反应直至融合孔的扩张。在这里，我们回顾了最近的进展，了解SNARE介导的膜融合的分子模拟。
SNARE molecules are the core constituents of the protein machinery that facilitate fusion of synaptic vesicles with the presynaptic plasma membrane, resulting in the release of neurotransmitter. On a molecular level, SNARE complexes seem to play a quite versatile and involved role during all stages of fusion. In addition to merely triggering fusion by forcing the opposing membranes into close proximity, SNARE complexes are now seen to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Here, we review recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations.