Pupillary light reflexes in patients with Leber's hereditary optic neuropathy
Pupillary light reflexes in patients with Leber's hereditary optic neuropathy
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DOI：
10.1007/s004170050220
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发表时间：
1999-03-01
影响因子：
2.7
通讯作者：
Wilhelm, H
中科院分区：
文献类型：
--
作者：
Lüdtke, H;Kriegbaum, C;Wilhelm, H
背景资料：根据最近的瞳孔描记术研究，患有Leber遗传性视神经病变（LHON）的患者显示出与正常人相同的瞳孔行为。由于这提出了许多问题的真实的性质的LHON和挑战我们的概念的传入瞳孔system.Methods：瞳孔功能进行了评估，在34名正常人和40例LHON患者，瞳孔光反射记录的紧凑型集成瞳孔描记器（CIP，AMTech）。在中间视觉条件下，以两种不同的刺激强度呈现200 ms的刺激。自动定义潜伏期、收缩幅度和基线直径。对20例不同视力的LHON患者与正常人及视力较好眼与视力较差眼的瞳孔光反射进行比较。LHON患者的瞳孔光反射的潜伏期延长了约20 ms，明亮刺激的振幅明显较小。结论：本研究结果证实LHON确实是一种视神经疾病，瞳孔对光反射不正常，
Background: According to a recent pupillographic study, patients with Leber's hereditary optic neuropathy (LHON) show the same pupillary behaviour as normals. Because this raises many questions concerning the real nature of LHON and challenges our concept of the afferent pupillary system, we tried to verify the results of this study.Methods: Pupillary function was assessed in 34 normal subjects and 40 patients with LHON, Pupillary light reflexes were recorded by means of the Compact Integrated Pupillograph (CIP, AMTech). Under mesopic conditions 200-ms stimuli were presented at two different stimulus intensities. Latency, constriction amplitude and baseline diameter were defined automatically. Pupil light re flexes were compared between LHON patients and normals and between the better and the worse eye in 20 LHON patients with different visual acuities.Results: For both stimuli there were significant differences in latency between LHON patients and controls. The latency of the pupil light reflex proved to be about 20 ms longer for LHON patients, and the amplitude was significantly smaller for the bright stimulus. Within LHON patients, the eyes with the worse visual acuity had a significantly smaller constriction amplitude than the eyes with the better visual acuity.Conclusion: The results of our study confirm that LHON really is an optic nerve disease and that the pupillary light reflexes are not normal,