Anti-inflammatory effects of interleukin-19 in vascular disease.
Anti-inflammatory effects of interleukin-19 in vascular disease.
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DOI：
10.1155/2012/253583
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发表时间：
2012
影响因子：
2
通讯作者：
Autieri MV
中科院分区：
文献类型：
--
作者：
England RN;Autieri MV
尽管积极的饮食调整、降脂药物和其他介入性药物治疗，血管疾病仍然是西方世界死亡的主要原因。它是一个重大的医学和社会经济问题，导致包括心肌梗死、中风、肾功能衰竭和外周血管疾病在内的多种疾病的死亡。随着肥胖、代谢综合征和2型糖尿病等并存疾病患者的增加，血管疾病的发病率和死亡率预计会恶化。动脉粥样硬化、再狭窄和移植物血管病变等血管疾病被认为是炎症的驱动因素，因此，介导炎症的细胞因子不仅是合理治疗的重要靶点，而且本身也可以被认为是可能的治疗手段。在这篇文章中，我们将研究炎症细胞因子和淋巴细胞Th1/Th2极性在血管炎症中的作用，重点是动脉粥样硬化性血管疾病。然后，我们将介绍一种最近描述的Th2白介素IL-19(IL-19)，作为一种以前未被认识的血管炎性疾病的介质。我们将回顾目前对IL-19在健康和疾病中的理解，并提出IL-19可能作为一种潜在的治疗手段来对抗血管炎症性疾病。
Despite aggressive dietary modification, lipid-lowering medications, and other interventional medical therapy, vascular disease continues to be a leading cause of mortality in the western world. It is a significant medical and socioeconomic problem contributing to mortality of multiple diseases including myocardial infarction, stroke, renal failure, and peripheral vascular disease. Morbidity and mortality of vascular disease are expected to worsen with the increasing number of patients with comorbid conditions such as obesity, metabolic syndrome, and diabetes mellitus type 2. Vascular diseases such as atherosclerosis, restenosis, and allograft vasculopathy are recognized to be driven by inflammation, and as such, cytokines which mediate inflammation not only represent important targets of rational therapy, but also can be considered as possible therapeutic modalities themselves. In this paper, we will examine the role of inflammatory cytokines and lymphocyte Th1/Th2 polarity in vascular inflammation, with a focus on atherosclerotic vascular disease. We will then introduce a recently described Th2 interleukin, interleukin-19 (IL-19), as a previously unrecognized mediator of vascular inflammatory disorders. We will review our current understanding of this interleukin in health and disease and present the possibility that IL-19 could represent a potential therapeutic to combat vascular inflammatory disease.