Pulmonary function and airway responsiveness during long-term therapy with captopril.
Pulmonary function and airway responsiveness during long-term therapy with captopril.
复制标题
卡托普利长期治疗期间的肺功能和气道反应性。
DOI：
10.1001/jama.1989.03420030087036
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Y. Lacourciére
中科院分区：
文献类型：
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作者：
L. Boulet;J. Milot;N. Lampron;Y. Lacourciére
血管紧张素转换酶抑制剂有时会引起咳嗽;其机制尚不清楚。因此，我们研究了开搏通门诊治疗对15名高血压受试者肺功能和对乙酰甲胆碱非特异性支气管反应性的影响。肺容量，呼气流量和非特异性支气管反应乙酰甲胆碱使用剂量高达64 g/L的前和4周和8周后，卡托普利治疗开始测量。在整个研究过程中，受试者记录呼吸道症状和呼气流速峰值。在4例受试者中，持续性咳嗽的发生与使用卡托普利有关，但这与气流阻塞或支气管高反应性的发生无关。与基线评估时的61.6 +/- 1.2 g/L相比，在8周的卡托普利治疗后，导致1 s内用力呼气量下降20%的乙酰甲胆碱平均激发浓度为43.6 +/-1.8 g/L。我们的结论是，有没有显着的变化，肺功能在治疗期间与卡托普利。与这种药物相关的咳嗽的发生与气流阻塞或气道高反应性的发生无关。
Angiotensin-converting enzyme inhibitors sometimes cause cough; the mechanism is unknown. We therefore studied the effects of ambulatory treatment with captopril on pulmonary function and on nonspecific bronchial responsiveness to methacholine in 15 hypertensive subjects. Lung volumes, expiratory flows and nonspecific bronchial responsiveness to methacholine using doses up to 64 g/L were measured before and four and eight weeks after captopril treatment was started. Throughout the study the subjects recorded respiratory symptoms and peak expiratory flow rates. In four subjects a persistent cough developed related to the use of captopril, but this was not associated with the development of airflow obstruction or bronchial hyperresponsiveness. The mean provocative concentration of methacholine that resulted in a 20% fall in the forced expiratory volume in 1 s was 43.6 +/- 1.8 g/L after eight weeks of captopril treatment compared with 61.6 +/- 1.2 g/L at the baseline evaluation. We concluded that there was no significant change in lung function during treatment with captopril. The development of a cough related to this medication is not associated with the development of airflow obstruction or airway hyperresponsiveness.