Basement Membrane in Pancreatic Islet Function
Basement Membrane in Pancreatic Islet Function
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DOI：
10.1007/978-90-481-3271-3_10
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发表时间：
2010-01-01
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影响因子：
--
通讯作者：
Lammert, Eckhard
中科院分区：
文献类型：
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作者：
Kragl, Martin;Lammert, Eckhard
临床上应用胰岛移植治疗糖尿病患者面临着各种并发症。目前，胰岛的体外扩增是以其基本特征为代价的，这些特征是胰岛素的产生和释放。然而，最近发现血管/β细胞相互作用是胰岛素转录、分泌和增殖的一个重要方面，这可能会为我们指出如何克服这个问题的方法。β细胞的正确功能取决于基底膜的存在，基底膜是一种位于小鼠和人类胰岛血管壁周围的特殊细胞外基质。在本章中，我们总结了血管基底膜如何影响胰岛素转录，胰岛素分泌和β细胞增殖。此外，对基底膜成分及其与细胞表面受体的相互作用作了简要概述。
Clinical treatment of diabetic patients by islet transplantation faces various complications. At present, in vitro expansion of islets occurs at the cost of their essential features, which are insulin production and release. However, the recent discovery of blood vessel/beta-cell interactions as an important aspect of insulin transcription, secretion, and proliferation might point us to ways of how this problem could be overcome.The correct function of beta-cells depends on the presence of a basement membrane, a specialized extracellular matrix located around the blood vessel wall in mouse and human pancreatic islets. In this chapter, we summarize how the vascular basement membrane influences insulin transcription, insulin secretion, and beta-cell proliferation. In addition, a brief overview about basement membrane components and their interactions with cell surface receptors is given.