A missing link between depression models: Forced swimming test, helplessness and passive coping in genetically heterogeneous NIH-HS rats
A missing link between depression models: Forced swimming test, helplessness and passive coping in genetically heterogeneous NIH-HS rats
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DOI：
10.1016/j.beproc.2020.104142
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发表时间：
2020-08-01
影响因子：
1.3
通讯作者：
Fernandez-Teruel, Alberto
中科院分区：
文献类型：
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作者：
Raez, Andrea;Oliveras, Ignasi;Fernandez-Teruel, Alberto
采用强迫游泳试验和双向主动逃避/回避任务中的无助反应研究了啮齿类动物的抑郁样症状和抗抑郁药物治疗。在这两个测试/任务中，动物都处于压力状态，已知会诱导几种反应，这些反应被认为与人类抑郁症的一些症状相似。然而，目前缺乏实验证据支持远交系大鼠在两种行为过程中表现出的行为反应之间的关联。本研究的目的是评估使用美国国立卫生研究院遗传异质性大鼠股票（即NIH-HS大鼠）的抑郁症模型的行为反应之间的可能关联。为此，97只NIH-HS大鼠接受两种行为程序（FST和固定比率2 -FR 2下的双向主动逃避任务）。比较在FST或FR 2无助任务中通过其高或低行为反应选择的大鼠亚组的统计分析显示了在两种测试中评估的反应之间的关联。具体而言，较高水平的挣扎（即大力游泳直接逃离FST）或固定在第一届会议的FST预测较少的响应失败的FR 2双向主动逃避（无助）任务的时间较短。同时，大鼠在FR 2任务中的反应失败的高或低评分的分层预测了它们在FST中的挣扎水平。因此，它是第一次证明，在一个测试中的被动应对反应是预测类似的应对方式在其他任务。目前的研究结果可能是相关的抑郁症模型的并发有效性。
The forced swimming test (FST) and helplessness reactions at two-way active escape/avoidance task are used in the study of depressive-like symptoms and antidepressant treatments in rodents. In both tests/tasks the animals are submitted to stressful situations, known to induce several responses that have been considered as parallels of some symptoms of the human depressive disorder. However, there is a lack of experimental evidence supporting associations between the behavioral responses displayed in both behavioral procedures by outbred rats. The objective of the present study was to evaluate the possible associations between the behavioral responses in both depression models using the National Institutes of Health genetically heterogeneous rat stock (i.e. NIH-HS rats). To this aim, 97 NIH-HS rats were submitted to both behavioral procedures (FST and two-way active escape task under a fixed ratio 2 - FR2). The statistical analyses comparing the sub-groups of rats selected by their high or low behavioral responses in either the FST or the FR2 helplessness task showed associations between the responses evaluated in both tests. Specifically, higher levels of struggling (i.e. vigorous swimming directed to escape from the FST) or less time of immobility in the first session of FST predicted lesser response failures in the FR2 two-way active escape (helplessness) task. In parallel, the stratification of rats for their high or low scores of response failures in the FR2 task was predictive of their levels of struggling in the FST. Thus, it is demonstrated for the first time that passive coping responses in one test are predictive of similar coping styles in the other task. The present findings may be relevant for the concurrent validity of both depression models.