ASSOCIATION BETWEEN SEVERITY OF ALCOHOLISM AND THE A1-ALLELE OF THE DOPAMINE D2-RECEPTOR GENE TAQI-A RFLP IN JAPANESE
ASSOCIATION BETWEEN SEVERITY OF ALCOHOLISM AND THE A1-ALLELE OF THE DOPAMINE D2-RECEPTOR GENE TAQI-A RFLP IN JAPANESE
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DOI：
10.1016/0006-3223(93)90309-2
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发表时间：
1993-01-15
影响因子：
10.6
通讯作者：
TORU, M
中科院分区：
文献类型：
--
作者：
ARINAMI, T;ITOKAWA, M;TORU, M
对78例日本酒精者进行了多巴胺D2受体基因TaqI A限制性片段长度多态性(RFLP)与酒精中毒的等位基因关联分析，并与日本对照组进行了比较。在100名未筛查的日本对照组中，发现A1等位基因的频率(0.42)明显高于白人人群中的报告。在确定了严重程度的70名酗酒者中，43名重度酗酒者中有77%的人存在A1等位基因，27名轻度酗酒者中有59%的人存在A1等位基因。A1等位基因在60岁或以上的酗酒者中的出现频率(42%)显著低于60岁以下的酗酒者(74%)。在60岁以下的受试者中，在35名重度酗酒者中有83%的人存在A1等位基因，明显高于35名非酒精对照组中60%的人。所有7名A1等位基因纯合子的酗酒者都被归类为重度。酒精中毒的平均严重程度依次为A2/A2、A1/A2和A1/A1。这些数据表明，A1等位基因与日本人群中的严重酒精中毒有关，这种影响与一个对酒精中毒有微小但不可忽略的相加效应的遗传因素有关或存在连锁不平衡。
The allelic association of TaqI A restriction fragment length polymorphism (RFLP) of the dopamine D2 receptor gene with alcoholism was examined in 78 Japanese alcoholics and compared with Japanese controls. A significantly higher frequency of the A1 allele (0.42) was found in 100 Japanese unscreened controls compared with those reported in white populations. Among 70 alcoholics whose severities were determined, the A1 allele was present in 77% of 43 more severe alcoholics and in 59% of 27 less severe alcoholics. The A1 allele was present significantly less frequently in the alcoholics at the age of 60 or older (42%), compared with those under the age of 60 (74%). In the subjects under the age of 60, the A1 allele was present in 83% of the 35 more severe alcoholics, being significantly more frequent than in 60% of the 35 nonalcoholic controls. All of the 7 alcoholics homozygous for the A1 allele were classified as severe. The average severity of alcoholism increased in the order A2/A2, A1/A2, and A1/A1 genotypes. These data suggest that the A1 allele is associated with severe alcoholism in the Japanese population and that the effect is related to or has a linkage disequilibrium with a genetic factor that has a small but not negligible additive effect on alcoholism.