CONGENITAL HEART-DEFECTS AND TWINNING
CONGENITAL HEART-DEFECTS AND TWINNING
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DOI：
10.1017/s0001566000007510
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
CORNEY, G
中科院分区：
文献类型：
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作者：
BURN, J;CORNEY, G
在五个中心对患有心脏缺陷的双胞胎或三胞胎进行的初步分析证实了早期的建议，即即使排除了持续性动脉导管和连体双胞胎，单卵（MZ）双胞胎在患有心脏缺陷的双胞胎中的代表性也过高。MZ双胞胎个体的心血管畸形风险约为DZ双胞胎和单胞胎的两倍。这表明，孪生过程本身会影响一对。偏侧性障碍（“镜像”）可能是比双胞胎输血更重要的机制。过去不适当地使用双胎法造成遗传因素在先天性心脏病病因中的重要性被低估。尽管如此，双胞胎确实提供了一个有用的例子，说明表观遗传因素在心脏发育中的可能重要性。
A preliminary analysis of twins or triplets with heart defects, ascertained in five centres, confirms earlier suggestions that monozygotic (MZ) twins are over represented among twins with heart defects, even after excluding persistent ductus arteriosus and conjoined twins. An MZ twin individual has a risk of cardiovascular malformation approximately twice that of DZ twins and singletons. It is suggested that the twinning process itself affects one of the pair. Disturbance of laterality (‘mirror imaging’) is probably a more important mechanism than twin-twin transfusion. Inappropriate use of the twin method in the past has caused the importance of genetic factors in the etiology of congenital heart defects to be underestimated. Neverthless, twins do provide a useful illustration of the likely importance of epigenetic factors in heart development.