Antagonism of the hypnotic effect of ethanol in mice by an alpha-1 adrenoceptor agonist
Antagonism of the hypnotic effect of ethanol in mice by an alpha-1 adrenoceptor agonist
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α-1肾上腺素受体激动剂对小鼠乙醇催眠作用的拮抗作用
DOI：
10.1016/0028-3908(85)90048-6
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发表时间：
1985
影响因子：
4.7
通讯作者：
C. K. Kodama
中科院分区：
文献类型：
--
作者：
M. Menon;C. K. Kodama
脂溶性α1肾上腺素受体激动剂2-（2-氯-5-三氟甲基苯基亚氨基）咪唑烷（St 587）可拮抗乙醇对C57 B1/6和CD-1小鼠的催眠作用。在Swiss-Webster小鼠中，St 587的作用较弱，而在BALB/c小鼠中，该药物增强了乙醇催眠作用。St 587不增强乙醇的消除。Cirazoline是一种比St 587更强的α1-肾上腺素受体激动剂，其对抗乙醇诱导的催眠作用相对更强。虽然St 587似乎是通过其α1-肾上腺素受体激动作用发挥其乙醇拮抗作用，但也必须考虑其他影响因素。St 587可能对理解乙醇的作用机制和治疗急性乙醇中毒有价值。
A lipid soluble α1-adrenoceptor agonist 2-(2-chloro-5-trifluoromethylphenylimino) imidazolidine (St 587) antagonized the hypnotic effect of ethanol in C57B1/6 and CD-1 mice. In Swiss-Webster mice the effect of St 587 was weak and in BALB/c mice this drug potentiated ethanol hypnosis. St 587 did not enhance the elimination of ethanol. Cirazoline, an α1-adrenoceptor agonist which is more potent than St 587, was relatively more effective in antagonizing the ethanol-induced hypnosis. Though it appears that St 587 exerted its ethanol antagonism by virtue of its α1-adrenoceptor agonistic effect, other contributing factors may also have to be considered. St 587 may prove to be of value in understanding the mechanism of action of ethanol and in the treatment of acute ethanol intoxication.