Genome-wide characterization of Mediator recruitment, function, and regulation.
Genome-wide characterization of Mediator recruitment, function, and regulation.
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介体招募、功能和调节的全基因组表征。
DOI：
10.1080/21541264.2017.1291082
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Zentner,GabrielE
中科院分区：
文献类型：
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作者：
Grünberg,Sebastian;Zentner,GabrielE
介体是RNA聚合酶II（RNAPII）转录广泛需要的保守且必需的辅激活因子复合物。最近在芽殖酵母中对介体结合的全基因组研究揭示了对这个关键复合物的功能的新见解，并提出了关于其在基因表达调控中的作用的新问题。
Mediator is a conserved and essential coactivator complex broadly required for RNA polymerase II (RNAPII) transcription. Recent genome-wide studies of Mediator binding in budding yeast have revealed new insights into the functions of this critical complex and raised new questions about its role in the regulation of gene expression.