Abdominal obesity, glucose intolerance and decreased high-density lipoprotein cholesterol as components of the metabolic syndrome are associated with the development of colorectal cancer
Abdominal obesity, glucose intolerance and decreased high-density lipoprotein cholesterol as components of the metabolic syndrome are associated with the development of colorectal cancer
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DOI：
10.1007/s10654-018-0440-6
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发表时间：
2018-11-01
影响因子：
13.6
通讯作者：
Kim, Nayoung
中科院分区：
文献类型：
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作者：
Choi, Yoon Jin;Lee, Dong Ho;Kim, Nayoung
代谢综合征（MetS）及其组成部分被认为与结直肠癌（CRC）的发展有关。然而，根据性别或肿瘤的解剖位置，结果往往不一致。本研究旨在通过性别和肿瘤位置探讨met及其成分与结直肠癌发展之间的关系。我们评估了2009年至2012年间接受定期健康检查的22,809,722名国家半强迫症队列韩国人的数据。与没有met成分的受试者相比，met患者发生结直肠癌的风险比为1.22(95%可信区间[CI] 1.20-1.24)，男性比女性更明显(HR 1.41 95% CI 1.37-1.44 vs HR 1.23 95% CI 1.20-1.27， P为相互作用
Metabolic syndrome (MetS) and its components has been thought to be involved in the development of colorectal cancer (CRC). However, the results is often inconsistent according to gender or anatomical location of tumor. This study aimed to investigate the association between MetS and its components and CRC development by gender and tumor location. We evaluated the data of 22,809,722 Korean individuals of the National semi-compulsive cohort who underwent regular health check-ups between 2009 and 2012. Compared to subjects without MetS components, the hazard ratio for CRC development in patients with MetS was 1.22 (95% Confidence Interval [CI] 1.20-1.24) and this association was more prominent in men than in women (HR 1.41 95% CI 1.37-1.44 vs. HR 1.23 95% CI 1.20-1.27, P for interaction