Decreased functional connectivity density in pain-related brain regions of female migraine patients without aura
Decreased functional connectivity density in pain-related brain regions of female migraine patients without aura
复制标题
无先兆女性偏头痛患者疼痛相关脑区功能连接密度降低
DOI：
10.1016/j.brainres.2015.12.007
复制
发表时间：
2016-02-01
期刊：
影响因子：
2.9
通讯作者：
Zhao, Ling
中科院分区：
文献类型：
--
作者：
Gao, Qing;Xu, Fei;Zhao, Ling
偏头痛是最常见的神经系统疾病之一，被认为与中枢神经系统功能障碍有关。本研究的目的是检测无先兆偏头痛（MWoA）全脑大尺度网络中功能连接结构的改变。同时，可以识别出MWoA靶向的脑功能中枢。应用一种基于体素的功能连接密度（FCD）映射方法对55例女性MWoA患者和44例年龄匹配的女性健康对照（HC）静息状态功能磁共振成像数据进行分析。与HC相比，MWoA患者在双侧海马、双侧岛、右侧杏仁核、右侧扣带前皮层、双侧壳核、双侧尾状核和前额叶皮层均出现近程FCD值异常。结果表明，在女性MWoA中，这些与疼痛相关的大脑区域内连通性降低。此外，MWoA组左前额叶皮层、壳核和尾状核的近程FCD值与病程呈显著负相关，表明偏头痛反复发作可能持续影响这些脑中枢的静息状态功能连接结构。我们的研究结果揭示了女性MWoA的脑中枢功能障碍，并提示左侧前额叶皮层、壳核和尾状核是反映女性MWoA病程的敏感神经影像学标志物。这可能为我们了解MWoA中大规模脑网络的组织变化提供新的见解。(C) 2015 Elsevier B.V.版权所有
Migraine is one of the most prevalent neurological disorders which is suggested to be associated with dysfunctions of the central nervous system. The purpose of the present study was to detect the altered functional connectivity architecture in the large-scale network of the whole brain in migraine without aura (MWoA). Meanwhile, the brain functional hubs which are targeted by MWoA could be identified. A new voxel-based method named functional connectivity density (FCD) mapping was applied to resting-state functional magnetic resonance imaging data of 55 female MWoA patients and 44 age matched female healthy controls (HC). Comparing to HC, MWoA patients showed abnormal short-range FCD values in bilateral hippocampus, bilateral insula, right amygdale, right anterior cingulate cortex, bilateral putamen, bilateral caudate nucleus and the prefrontal cortex. The results suggested decreased intraregional connectivity of these pain-related brain regions in female MWoA. In addition, short-range FCD values in left prefrontal cortex, putamen and caudate nucleus were significantly negatively correlated with duration of disease in MWoA group, implying the repeated migraine attacks over time may consistently affect the resting-state functional connectivity architecture of these brain hubs. Our findings revealed the dysfunction of brain hubs in female MWoA, and suggested the left prefrontal cortex, putamen and caudate nucleus served as sensitive neuroimaging markers for reflecting the disease duration of female MWoA. This may provide us new insights into the changes in the organization of the large-scale brain network in MWoA. (C) 2015 Elsevier B.V. All rights reserved.