IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
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DOI：
10.1016/j.biochi.2007.09.003
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发表时间：
2008-04-01
期刊：
影响因子：
3.9
通讯作者：
Giudicelli, Veronique
中科院分区：
文献类型：
--
作者：
Duroux, Patrice;Kaas, Quentin;Giudicelli, Veronique
IMGT (R)，国际 ImMunoGeneTics 信息系统 (R) (http://imgt.cines.fr)，是免疫遗传学和免疫信息学的参考。 IMGT 对复杂的免疫遗传学数据进行标准化和管理，其中包括免疫球蛋白 (IG) 或抗体、T 细胞受体 (TR)、主要组织相容性复合物 (MHC) 以及属于免疫球蛋白超家族 (IgSF) 和 MHC 超家族 (MhcSF) 的免疫系统相关蛋白 (RPI)。 IMGT 数据的准确性和一致性以及不同 IMGT 组件（数据库、工具和网络资源）之间的一致性基于 IMGT-ONTOLOGY，这是免疫遗传学和免疫信息学的第一个本体。 IMGT-本体通过依靠七个公理“识别”、“描述”、“分类”、“计数”、“定位”、“方向”和“目标”的不同方面来管理免疫遗传学知识，这些公理假设必须识别、描述、分类、计数、本地化、定向以及获得它们的方式的对象、过程和关系必须确定。这些公理构成了形式 IMGT-本体论，也称为 IMGT-万花筒。通过IG分子综合的例子，详细说明了由“识别”、“描述”、“分类”和“数字”公理生成的概念及其主要实例和语义关系。这些公理对于分子免疫遗传学知识的概念化至关重要，可用于生成分子、细胞、组织、器官、生物体或群体水平的多尺度方法的概念，强调应用领域的概括。通过这种方式，形式 IMGT 本体论代表了系统生物学中本体论阐述的范例。 (C) 2007 Elsevier Masson SAS。版权所有。
IMGT (R), the international ImMunoGeneTics information system (R) (http://imgt.cines.fr), is the reference in immunogenetics and immunoinformatics. IMGT standardizes and manages the complex immunogenetic data which include the immunoglobulins (IG) or antibodies, the T cell receptors (TR), the major histocompatibility complex (MHC) and the related proteins of the immune system (RPI) which belong to the immunoglobulin superfamily (IgSF) and the MHC superfamily (MhcSF). The accuracy and consistency of IMGT data and the coherence between the different IMGT components (databases, tools and Web resources) are based on IMGT-ONTOLOGY, the first ontology for immunogenetics and immunoinformatics. IMGT-ONTOLOGY manages the immunogenetics knowledge through diverse facets relying on seven axioms, "IDENTIFICATION", "DESCRIPTION", "CLASSIFICATION", "NUMEROTATION", "LOCALIZATION", "ORIENTATION" and "OBTENTION", that postulate that objects, processes and relations have to be identified, described, classified, numerotated, localized, orientated, and that the way they are obtained has to be determined. These axioms constitute the Formal IMGT-ONTOLOGY, also designated as IMGT-Kaleidoscope. Through the example of the IG molecular synthesis, the concepts generated from the "IDENTIFICATION", "DESCRIPTION", "CLASSIFICATION" and "NUMEROTATION" axioms are detailed with their main instances and semantic relations. The axioms have been essential for the conceptualization of the molecular immunogenetics knowledge and can be used to generate concepts for multi scale approaches at the molecule, cell, tissue, organ, organism or population level, emphasizing the generalization of the application domain. In that way the Formal IMGT-ONTOLOGY represents a paradigm for the elaboration of ontologies in system biology. (C) 2007 Elsevier Masson SAS. All rights reserved.