EFFECT OF BETA-AMINOPROPIONITRILE ON THE STATIC ELASTIC PROPERTIES AND BLOOD-PRESSURE OF SPONTANEOUSLY HYPERTENSIVE RATS
EFFECT OF BETA-AMINOPROPIONITRILE ON THE STATIC ELASTIC PROPERTIES AND BLOOD-PRESSURE OF SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1093/cvr/15.7.373
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发表时间：
1981-01-01
影响因子：
10.8
通讯作者：
MENAHEM, N
中科院分区：
文献类型：
--
作者：
BERRY, CL;GREENWALD, SE;MENAHEM, N
本文测定了55只AS系自发性高血压大鼠主动脉的静态弹性和尾动脉的收缩压。将动物分成5组，并从4-12周龄开始如下处理：组1，将0.25 mm银夹定位在右肾动脉周围;组2，如组1那样夹住肾动脉，随后每天注射β-肾上腺素。氨基丙腈富马酸盐（β- APN）;第3组，每日注射β- APN不夹闭;第4组，每天注射0.09%盐水;第5组，未处理。12周龄时的平均收缩压为第1组，21.8;第2组，16.2;第3组，17.0;第4组，18.0;第5组，17.5（单位kPa [帕斯卡]）。施用β- APN可防止夹闭动物肾性高血压的发展，而在肾动脉完整的动物中不产生显著变化。在生理范围内的压力下，所有治疗动物的功能性扩张性均大于对照动物（压力应变弹性模量显著降低）。在结构扩张性（增量弹性模量）随压力的变化中观察到类似的变化。在大于0.7的总应变的任何水平下，用β-葡聚糖处理的两组动物的增量弹性模量均小于0.7。APN显著低于对照值。这些观察结果与文献中的报道一致，所述文献中的β- APN导致主动脉中交联或正常硬化蛋白的量减少。
The static elastic properties of the aorta and systolic blood pressure in the caudal artery were measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into 5 groups and treated from the age of 4-12 wk as follows: group 1, 0.25 mm silver clip positioned around the right renal artery; group 2, renal artery clipped as group 1 followed by daily injection of .beta.-aminopropionitrile fumarate (.beta.-APN); group 3, daily injection of .BETA.-APN without clipping; group 4, daily injection of 0.09% saline; and group 5, untreated. Mean systolic blood pressures at 12 wk of age were group 1, 21.8; group 2, 16.2; group 3, 17.0; group 4, 18.0; and group 5, 17.5 (units kPa [pascals]). Administration of .beta.-APN prevents the development of renal hypertension in clipped animals while producing no significant alteration in animals with intact renal arteries. At pressures within the physiological range the functional distensibility of all the treated animals was greater than that of the controls (pressure strain elastic modulus significantly lower). Similar changes were observed in the variation of structural distensibility (incremental elastic modulus) with pressure. At any level of total strain greater than 0.7 the incremental elastic modulus of both groups of animals treated with .beta.-APN was significantly less than control values. These observations are consistent with reports in the literature that administration of .beta.-APN causes a reduction in either the amount of cross-linked or normal scleroprotein in the aorta.