Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata
Efferent projections of infralimbic and prelimbic areas of the medial prefrontal cortex in the Japanese monkey, Macaca fuscata
复制标题
DOI：
10.1016/s0006-8993(00)03013-4
复制
发表时间：
2001-01-05
期刊：
影响因子：
2.9
通讯作者：
Nakanoh, K
中科院分区：
文献类型：
--
作者：
Chiba, T;Kayahara, T;Nakanoh, K
边缘下区（inforimbic area，IL）和边缘前区（prelimbic area，PL）被认为是内侧前额叶皮层的自主运动区。本研究旨在揭示猴IL和PL的投射部位。用生物素葡聚糖胺作为顺行示踪剂的黑尾猕猴。IL和PL密集投射于尾状核腹内侧核、杏仁核的壳和角、杏仁核外侧基底小细胞核和大细胞副基底核、外侧视前区、下丘脑腹内侧核、结节乳头核、丘脑背内侧核大细胞内侧部和小细胞背侧部、中脑内侧枕核的重聚和内侧部分以及导水管周围灰质（PAGdl）的背外侧部分。中度至弱投射的区域为无颗粒岛叶皮质的中间和外侧部分、12区眶部、颞极皮质的无颗粒和无颗粒部分（TPa-g）、听颞叶皮质、隔外侧和内侧（MS）核、终纹床核。Broca对角手、无名质和内侧视前区、下丘脑背内侧核、外侧核和后核、大细胞外侧基底核和外侧杏仁核、丘脑的带旁核、室旁核（PV）、环间内侧核（IAM）、网状核、中央内侧核（CeM）、束旁核（PF）和界核、外侧缰核、脚桥核。外侧丘系核背侧部、腹侧被盖区、中缝背核、上级中央核。臂旁内侧核、臂旁外侧核和蓝斑核。在下丘脑穹窿周围核和黑质腹侧部可见少量散在终末。PL和24区的特点是投射到内嗅（Ent）和梨状（Pir）皮质以及丘脑腹前核（VAmc）的大细胞部分。不同核团的终末分支形态不同，可能反映了神经终末与突触后树突之间的突触相互作用。PL唯一地投射到Ent. Pir和VAmc，IL唯一地投射到TPa-g、MS、IAM、CeM、MDpc、PF、PBI和LC。IL比PL更强地投射到Acb、杏仁核、PV、TM、VTA和PAGdl的壳。目前的结果支持了这样的假设：IL是灵长类动物主要的皮质自主运动区域，PL整合了边缘系统和自主神经输入。(C)2001 Elsevier Science B. V.保留所有权利。
The infralimbic area (IL) and prelimbic area (PL) have been postulated as an autonomic motor region in the medial prefrontal cortex. The present study was conducted to reveal the projection sites of IL and PL of the monkey. Macaca fuscata, using biotinylated dextran amine as an anterograde tracer. IL and PL projected densely to the ventromedial caudate nucleus, the cure and shell of the nucleus accumbens (Acb), parvicellular lateral basal and magnocellular accessory basal nuclei of the amygdala, lateral preoptic area, ventromedial hypothalamic nucleus, tubero-mammillary nucleus (TM), medial part of the magnocellular and dorsal part of the parvicellular (MDpc) dorsomedial thalamic nuclei, reunience and medial part of the medial pulvinar nucleus, and dorso-lateral part of the periaqueductal gray (PAGdl) in the mesencephalon. Moderately to weakly projected areas were the intermediate and lateral parts of the agranular insular cortex, orbital part of area 12, agranular and dysgranular part of the temporal pole cortex (TPa-g), auditory temporal cortex, lateral and medial (MS) septal nuclei, bed nucleus of the stria terminalis. diagonal hand of Broca, substantia innominata, and medial preoptic area, dorsomedial, lateral, and posterior hypothalamic nuclei, magnocellular lateral basal and lateral amygdaloid nuclei, paratenial, paraventricular (PV), inter-antero-medial (IAM), reticular, central medial (CeM), parafascicular (PF) and limitans nuclei of the thalamus, lateral habenular nucleus, pedunculo-pontine nucleus. dorsal part of the lateral lemniscal nucleus, ventral tegmental area (VTA), dorsal raphe, superior central nucleus. medial and lateral parabrachial nuclei (PBI) and nucleus locus coeruleus (LC). A few scattered terminals were observed in the perifornical nucleus of the hypothalamus and substantia nigra pars compacta. PL and area 24 were characterized by projections to the entorhinal (Ent) and piriform (Pir) cortex as well as to the magnocellular part of the ventral anterior thalamic nucleus (VAmc). The morphology of the terminal arborization in each nuclei was different in appearance, perhaps reflecting the synaptic interaction between the nerve terminals and postsynaptic dendrites. PL projected uniquely to Ent. Pir and VAmc and IL projected uniquely to TPa-g, MS, IAM, CeM, MDpc, PF, PBI and LC. IL projected more strongly than PL to the shell of Acb, amygdaloid nuclei, PV, TM, VTA and PAGdl. The present results support the hypothesis that IL is a major cortical autonomic motor area and PL integrates limbic and autonomic inputs in the primate. (C) 2001 Elsevier Science B.V. All rights reserved.