Distribution of heat-stable enterotoxin/guanylin receptors in the intestinal tract of man and other mammals.
Distribution of heat-stable enterotoxin/guanylin receptors in the intestinal tract of man and other mammals.
复制标题
热稳定肠毒素/鸟苷蛋白受体在人和其他哺乳动物肠道中的分布。
作者：
William J. Krause;G. Cullingford;Ronald H. Freeman;S. Eber;Kenneth C. Richardson;K. Fok;M. Currie;L. R. Forte
研究人员对人类肠道以及几种真兽类和后兽类哺乳动物的肠道进行了热稳定肠毒素 (ST)/鸟苷蛋白受体的分布检查。这些受体仅限于内腔内衬的肠上皮，并在所有检查物种的小肠和结肠的整个长度上形成肠腺。在人类和大多数其他哺乳动物中，沿小肠纵轴远端的受体密度似乎有所下降。在形成肠壁的其他层中没有观察到 ST/鸟苷蛋白受体。沿着人类小肠（绒毛/隐窝单位）的垂直轴，以及大多数其他哺乳动物的垂直轴，位于绒毛基部附近的肠细胞和形成肠腺近端部分的肠细胞中受体密度最大。 ST/鸟苷蛋白受体大部分局限于形成微绒毛边界的质膜区域。在人类和其他检查物种的结肠中，形成肠腺近端区域的肠细胞中的受体密度最大。受体存在于结肠腔内的肠上皮中，但数量通常较少。负鼠 (Didelphis virginiana) 和浣熊 (Procyon lotor) 对大肠杆菌 ST 和鸟苷蛋白的细胞 cGMP 积累反应的分布表明，近端小肠比远端小肠具有更大的 cGMP 反应强度。近端结肠比远端结肠具有更强的 cGMP 反应，而远端结肠对 ST 或鸟苷蛋白没有显着的 cGMP 反应。
The human intestinal tract, as well as that of several eutherian and metatherian mammals, was examined for the distribution of heat-stable enterotoxin (ST)/guanylin receptors. These receptors were confined to the intestinal epithelium lining the lumen and forming the intestinal glands throughout the length of both the small intestine and colon of all species examined. In man and most other mammalian species, there appeared to be a decrease in receptor density distally along the longitudinal axis of the small intestine. ST/guanylin receptors were not observed in other strata forming the gut wall. Along the vertical axis of the human small intestine (villus/crypt unit), as well as that of most other mammals, receptor density was greatest in enterocytes located near the base of villi and in those forming the proximal portion of the intestinal glands. ST/guanylin receptors were for the most part confined to the region of the plasmalemma forming the microvillus border. In the colon of man and the other species examined, receptor density was greatest in enterocytes forming the proximal region of the intestinal glands. Receptors were present in the intestinal epithelium lining the lumen of the colon, but generally were fewer in number. The distribution of cellular cGMP accumulation responses to E. coli ST and guanylin in the opossum (Didelphis virginiana) and raccoon (Procyon lotor) revealed that proximal small intestine had greater magnitudes of cGMP responses than did the distal small intestine. Proximal colon had greater cGMP responses than distal colon, which had no significant cGMP responses to either ST or guanylin.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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DOI：
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期刊：
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影响因子：
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影响因子：
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作者：
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DOI：
--
发表时间：
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期刊：
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影响因子：
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